Goat Anti-ORC3L Polyclonal Antibody – Cat# MBS421369

(2ug/ml) staining of Hela lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence.

ORC3L Antibody – Goat Polyclonal

Name: ORC3L Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421369
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421369

MBS421369 is an antibody targeting ORC3L. Also known as Goat anti-ORC3L Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ORC3L, Polyclonal Antibody

Full Product Name

Goat anti-ORC3L Antibody

Product Gene Name

anti-ORC3L antibody

Product Synonym Names

ORC3L; origin recognition complex, subunit 3-like (yeast); LAT; ORC3; LATHEO; IMAGE50150; origin recognition complex, subunit 3 (yeast homolog)-like; OTTHUMP00000040611; homolog of latheo, Drosophila; RP3-486L4.1; origin recognition complex, subunit 3; ORC3L antibody; origin recognition complex; subunit 3-like (yeast) antibody; LAT antibody; ORC3 antibody; LATHEO antibody; IMAGE50150 antibody; origin recognition complex; subunit 3 (yeast homolog)-like antibody; OTTHUMP00000040611 antibody; homolog of latheo; Drosophila antibody; RP3-486L4.1 antibody; origin recognition complex; subunit 3 antibody

Immunogen Sequence

QKTDHVARLT WGGC

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

ORC3L peptide (MBS425966) is used for blocking the activity of ORC3L antibody (MBS421369)

Molecular Weight

65,929 Da

OMIM

604972

Immunogen

Peptide with sequence QKTDHVARLTWGGC, from the C Terminus of the protein sequence according to NP_862820.1; NP_036513.2.

Epitope

C Terminus

Note

This antibody is expected to recognize both reported isoforms (NP_862820.1 and NP_036513.2).

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-ORC3L antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-ORC3L antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.

Other Notes

Small volumes of anti-ORC3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ORC3L. It may not necessarily be applicable to this product.

NCBI GI #

32483369

NCBI GeneID

23595

NCBI Accession #

NP_862820.1

NCBI Related Accession #

NP_036513.2

UniProt Secondary Accession #

Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UG44; Q9UNT6; A2A2T5; B4E025

UniProt Related Accession #

Q9UBD5

GenBank Nucleotide #

NM_181837.2

NCBI Official Full Name

origin recognition complex subunit 3 isoform 1

NCBI Official Synonym Full Names

origin recognition complex subunit 3

NCBI Official Symbol

ORC3

NCBI Official Synonym Symbols

LAT; ORC3L; LATHEO

UniProt Protein Name

Origin recognition complex subunit 3

UniProt Synonym Protein Names

Origin recognition complex subunit Latheo

UniProt Gene Name

ORC3

UniProt Synonym Gene Names

LATHEO; ORC3L

UniProt Entry Name

ORC3_HUMAN

NCBI Protein Information

origin recognition complex subunit 3

NCBI Summary for ORC3L

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for ORC3L

ORC3L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 6q14.3-q16.1

Cellular Component: nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; origin recognition complex

Molecular Function: DNA replication origin binding; protein binding

Biological Process: DNA replication; G1/S transition of mitotic cell cycle

Research Articles on ORC3L

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ORC3L antibody

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The ORC Complex At The Origin Of Replication Pathway antibodies	Assembly Of The ORC Complex At The Origin Of Replication Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
Association Of Licensing Factors With The Pre-replicative Complex Pathway antibodies	Association Of Licensing Factors With The Pre-replicative Complex Pathway Diagram
CDC6 Association With The ORC:origin Complex Pathway antibodies	CDC6 Association With The ORC:origin Complex Pathway Diagram
CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies	CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram

Diseases associated with anti-ORC3L antibody

Disease Name	Pubmed Publications
Musculoskeletal Abnormalities Antibodies	>1 publications with ORC3L and Musculoskeletal Abnormalities

Organs/Tissues associated with anti-ORC3L antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5 publications with ORC3L and Brain
Nerve Antibodies	>2 publications with ORC3L and Nerve
Blood Antibodies	>2 publications with ORC3L and Blood
Embryonic Tissue Antibodies	>2 publications with ORC3L and Embryonic Tissue
Vascular Antibodies	>2 publications with ORC3L and Vascular
Ovary Antibodies	>1 publications with ORC3L and Ovary
Thymus Antibodies	>1 publications with ORC3L and Thymus
Eye Antibodies	>1 publications with ORC3L and Eye
Kidney Antibodies	>1 publications with ORC3L and Kidney
Bone Antibodies	>1 publications with ORC3L and Bone