PICK1 Antibody – Goat Polyclonal

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.

Protein type: Ligand, receptor tyrosine kinase; Adaptor/scaffold; Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cell junction; cytoplasm; cytoskeleton; Golgi apparatus; neuron projection; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane; synapse

Molecular Function: actin filament binding; ATPase activity; enzyme binding; G-protein-coupled receptor binding; identical protein binding; metal ion binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase C binding; receptor binding

Biological Process: cellular response to glucose starvation; DNA methylation during embryonic development; DNA methylation during gametogenesis; glial cell development; monoamine transport; neuronal ion channel clustering; positive regulation of receptor internalization; protein amino acid phosphorylation; protein kinase C activation; receptor clustering; retrograde vesicle-mediated transport, Golgi to ER