RARA Antibody – Goat

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: actin cytoskeleton; cell soma; cell surface; cytoplasm; dendrite; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: alpha-actinin binding; chromatin DNA binding; drug binding; enzyme binding; histone deacetylase binding; mRNA 5'-UTR binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor binding; retinoic acid binding; retinoic acid receptor activity; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription factor binding; translation repressor activity, nucleic acid binding; zinc ion binding

Biological Process: apoptotic cell clearance; embryonic camera-type eye development; female pregnancy; germ cell development; glandular epithelial cell development; hippocampus development; limb development; liver development; multicellular organism growth; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of granulocyte differentiation; negative regulation of interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translational initiation; negative regulation of tumor necrosis factor production; neural tube closure; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of neuron differentiation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein amino acid phosphorylation; regulation of myelination; regulation of synaptic plasticity; response to cytokine stimulus; response to estradiol stimulus; response to ethanol; response to retinoic acid; response to vitamin A; retinoic acid receptor signaling pathway; Sertoli cell fate commitment; signal transduction; spermatogenesis; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation

Disease: Acute Promyelocytic Leukemia