UEV2V2/MMS2 (UBE2V2) Antibody – Goat Polyclonal

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

UBE2V2: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8q11.21

Cellular Component: cytoplasm; nucleoplasm; nucleus; UBC13-MMS2 complex

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: cell proliferation; DNA double-strand break processing; double-strand break repair via nonhomologous end joining; error-free postreplication DNA repair; negative regulation of neuron apoptosis; positive regulation of DNA repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of synaptogenesis; postreplication repair; protein polyubiquitination; protein ubiquitination; regulation of DNA repair