P27KIP1/CDKN1B (CDKN1B) Antibody – Goat Polyclonal

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Protein type: Oncoprotein; Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 12p13.1-p12

Cellular Component: cytoplasm; cytosol; endosome; nucleoplasm; nucleus

Molecular Function: caspase activator activity; chaperone binding; cyclin-dependent protein kinase inhibitor activity; Hsp70 protein binding; protein binding; protein complex binding; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: autophagic cell death; caspase activation; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; inner ear development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; potassium ion transport; regulation of cyclin-dependent protein kinase activity; response to amino acid stimulus; response to cadmium ion; response to drug; response to estradiol stimulus; response to glucose stimulus; response to hypoxia; response to peptide hormone stimulus; sensory perception of sound

Disease: Multiple Endocrine Neoplasia, Type Iv