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TCL1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421413

MBS421413 is an antibody targeting Tcl1. Also known as Goat anti-Tcl1 (mouse) Antibody. Reactive in Expected from sequence similarity: Mouse. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Tcl1, Polyclonal Antibody
Full Product Name
Goat anti-Tcl1 (mouse) Antibody
Product Gene Name
Product Synonym Names
Tcl1; T-cell lymphoma breakpoint 1; Tcl1 antibody; T-cell lymphoma breakpoint 1 antibody; Tcl1 (mouse)
Immunogen Sequence
QLYPKDRYRS CD
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Mouse
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
14,112 Da
Immunogen
Peptide with sequence QLYPKDRYRSCD, from the internal region of the protein sequence according to NP_033363.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Tcl1 antibody
Peptide ELISA (EIA)
Application Notes for anti-Tcl1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments gave an approx 28kDa band in Rat Ovary lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 14.1kDa according to Mouse NP_033363.1. The 28kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-Tcl1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tcl1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
T-cell leukemia/lymphoma protein 1A isoform 1
NCBI Official Synonym Full Names
T cell lymphoma breakpoint 1
NCBI Official Symbol
Tcl1
NCBI Official Synonym Symbols
Tcl1a
UniProt Protein Name
T-cell leukemia/lymphoma protein 1A
UniProt Synonym Protein Names
Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1
UniProt Gene Name
Tcl1a
UniProt Synonym Gene Names
Tcl1; Oncogene TCL1
UniProt Entry Name
TCL1A_MOUSE
NCBI Protein Information
T-cell leukemia/lymphoma protein 1A

UniProt Comments for Tcl1

TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family.

Protein type: Protein kinase, regulatory subunit; Oncoprotein

Cellular Component: cell cortex; cytoplasm; endoplasmic reticulum; intracellular membrane-bound organelle; nucleus; pronucleus

Biological Process: stem cell maintenance
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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