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TBPL1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421476

MBS421476 is an antibody targeting TBPL1. Also known as Goat anti-TBPL1/TLF/TRF2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TBPL1/TLF/TRF2, Polyclonal Antibody
Full Product Name
Goat anti-TBPL1/TLF/TRF2 Antibody
Product Gene Name
anti-TBPL1 antibody
Product Synonym Gene Name
TLF; TRF2
Product Synonym Names
TBPL1; TRF2; TBP-like 1; TLP; STUD; MGC: 8389; MGC: 9620; TBP-like protein; TBP-related factor 2; 21-kDA TBP-like protein; second TBP of unique DNA; TATA box binding protein-related factor 2; TLF; TBPL1 antibody; TRF2 antibody; TBP-like 1 antibody; TLP antibody; STUD antibody; MGC: 8389 antibody; MGC: 9620 antibody; TBP-like protein antibody; TBP-related factor 2 antibody; 21-kDA TBP-like protein antibody; second TBP of unique DNA antibody; TATA box binding protein-related factor 2 antibody; TLF antibody; TBPL1 / TLF / TRF2
Immunogen Sequence
QIYPFVFESR KEIL
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
TBPL1 / TLF / TRF2 peptide (MBS426251) is used for blocking the activity of TBPL1/TLF/TRF2 antibody (MBS421476)
Molecular Weight
20,887 Da
OMIM
605521
Immunogen
Peptide with sequence C-QIYPFVFESRKEIL, from the C Terminus of the protein sequence according to NP_004856.1.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TBPL1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TBPL1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 20kDa band seen in Jurkat lysate [Predicted MW of 20kDa according to NP_004856]. Recommended for use at 1-3ug/ml.

Western Blot (WB) of anti-TBPL1 antibody

Staining (2ug/ml) of Jurkat lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-TBPL1 Polyclonal Antibody – Cat# MBS421476

Other Notes

Small volumes of anti-TBPL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TBPL1. It may not necessarily be applicable to this product.

NCBI GI #
4759234
NCBI GeneID
9519
NCBI Accession #
NP_004856.1
UniProt Secondary Accession #
O95753; Q9BWD5; Q9Z2Z0; A8K8F5
UniProt Related Accession #
P62380
GenBank Nucleotide #
NM_004865.3
NCBI Official Full Name
TATA box-binding protein-like protein 1
NCBI Official Synonym Full Names
TATA-box binding protein like 1
NCBI Official Symbol
TBPL1
NCBI Official Synonym Symbols
TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620
UniProt Protein Name
TATA box-binding protein-like protein 1
UniProt Synonym Protein Names
21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein
Protein Family
TATA box-binding protein-like protein
UniProt Gene Name
TBPL1
UniProt Synonym Gene Names
TLF; TLP; TLP21; TRF2; TRP; TBP-like protein 1; STUD; TBP-related factor 2
UniProt Entry Name
TBPL1_HUMAN
NCBI Protein Information
TATA box-binding protein-like protein 1

NCBI Summary for TBPL1

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
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UniProt Comments for TBPL1

TBPL1: Does not bind the TATA box. Has DNA-binding ability. Belongs to the TBP family.

Protein type: Transcription, coactivator/corepressor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cytoplasm; transcription factor TFIIA complex

Molecular Function: DNA binding; protein binding; transcription coactivator activity

Biological Process: acrosome formation; dTTP biosynthetic process; regulation of transcription, DNA-dependent; spermatid nuclear differentiation; transcription from RNA polymerase II promoter; transcription initiation
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Research Articles on TBPL1

1. results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TBPL1 antibody

 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram

Diseases associated with anti-TBPL1 antibody

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >3 publications with TBPL1 and Infertility, Male
 Oligospermia Antibodies  >1 publications with TBPL1 and Oligospermia
 Infertility, Female Antibodies  >1 publications with TBPL1 and Infertility, Female
 Adenocarcinoma Antibodies  >1 publications with TBPL1 and Adenocarcinoma

Organs/Tissues associated with anti-TBPL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with TBPL1 and Testis
 Embryonic Tissue Antibodies  >1 publications with TBPL1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with TBPL1 and Kidney
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