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AVPR1A Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421528

MBS421528 is an antibody targeting AVPR1A. Also known as Goat anti-AVPR1A Antibody. Reactive in Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
AVPR1A, Polyclonal Antibody
Full Product Name
Goat anti-AVPR1A Antibody
Product Gene Name
anti-AVPR1A antibody
Product Synonym Names
AVPR1A; arginine vasopressin receptor 1A; AVPR1; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; V1a vasopressin receptor; antidiuretic hormone receptor 1A; vascular/hepatic-type arginine vasopressin receptor; AVPR1A antibody; arginine vasopressin receptor 1A antibody; AVPR1 antibody; SCCL vasopressin subtype 1a receptor antibody; V1-vascular vasopressin receptor AVPR1A antibody; V1a vasopressin receptor antibody; antidiuretic hormone receptor 1A antibody; vascular/hepatic-type arginine vasopressin receptor antibody
Immunogen Sequence
CHPLKTLQQP ARRSR
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
AVPR1A peptide (MBS426799) is used for blocking the activity of AVPR1A antibody (MBS421528)
Molecular Weight
46,800 Da
OMIM
600821
Immunogen
Peptide with sequence CHPLKTLQQPARRSR, from the internal region of the protein sequence according to NP_000697.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-AVPR1A antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-AVPR1A antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 85kDa band observed in Human Brain (Frontal cortex) lysates and in Rat Brain lysates and in lysates of cell line NIH3T3 (calculated MW of 46.8kDa according to NP_000697.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Phalipou et al, J Biol Chem.1997 Oct 17;272(42): 26536-44; PMID: 9334232). Recommended concentration: 0. 03-0.1ug/ml.

Western Blot (WB) of anti-AVPR1A antibody

(0. 03ug/ml) staining of NIH3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-AVPR1A Polyclonal Antibody – Cat# MBS421528

Other Notes

Small volumes of anti-AVPR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AVPR1A. It may not necessarily be applicable to this product.

NCBI GI #
4502331
NCBI GeneID
552
NCBI Accession #
NP_000697.1
UniProt Related Accession #
P37288
GenBank Nucleotide #
NM_000706.4
NCBI Official Full Name
vasopressin V1a receptor
NCBI Official Synonym Full Names
arginine vasopressin receptor 1A
NCBI Official Symbol
AVPR1A
NCBI Official Synonym Symbols
V1aR; AVPR1; AVPR V1a
UniProt Protein Name
Vasopressin V1a receptor
UniProt Synonym Protein Names
AVPR V1a; Antidiuretic hormone receptor 1a; Vascular/hepatic-type arginine vasopressin receptor
Protein Family
Vasopressin V1a receptor
UniProt Gene Name
AVPR1A
UniProt Synonym Gene Names
AVPR1; V1aR
UniProt Entry Name
V1AR_HUMAN
NCBI Protein Information
vasopressin V1a receptor

NCBI Summary for AVPR1A

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
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UniProt Comments for AVPR1A

AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q14-q15

Cellular Component: cytoplasmic vesicle; cytosol; endosome; integral to plasma membrane; plasma membrane

Molecular Function: peptide binding; peptide hormone binding; protein binding; protein kinase C binding; V1A vasopressin receptor binding; vasopressin receptor activity

Biological Process: blood circulation; calcium-mediated signaling; cellular response to hormone stimulus; cellular response to water deprivation; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; generation of precursor metabolites and energy; grooming behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; phospholipase C activation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone stimulus; social behavior; sperm ejaculation; telencephalon development
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Research Articles on AVPR1A

1. Higher acute vulnerability to stress exists in persons with long AVPR1A RS3 alleles and increased arginine vasopressin levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AVPR1A antibody

 Reference Product  PubMed Publications
 AVP antibody  >42 publications with AVPR1A and AVP
 OXT antibody  >11 publications with AVPR1A and OXT
 AGTR1 antibody  >1 publications with AVPR1A and AGTR1
 BDKRB2 antibody  >1 publications with AVPR1A and BDKRB2
 TBXA2R antibody  >1 publications with AVPR1A and TBXA2R

Pathways associated with anti-AVPR1A antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective AVP Causes Neurohypophyseal Diabetes Insipidus (NDI) Pathway antibodies  Defective AVP Causes Neurohypophyseal Diabetes Insipidus (NDI) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disorders Of Transmembrane Transporters Pathway antibodies  Disorders Of Transmembrane Transporters Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-AVPR1A antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >651 publications with AVPR1A and Cardiovascular Diseases
 Hypertension Antibodies  >511 publications with AVPR1A and Hypertension
 Kidney Diseases Antibodies  >492 publications with AVPR1A and Kidney Diseases
 Heart Diseases Antibodies  >299 publications with AVPR1A and Heart Diseases
 Brain Diseases Antibodies  >265 publications with AVPR1A and Brain Diseases
 Hypotension Antibodies  >168 publications with AVPR1A and Hypotension
 Inflammation Antibodies  >116 publications with AVPR1A and Inflammation
 Bradycardia Antibodies  >87 publications with AVPR1A and Bradycardia
 Edema Antibodies  >83 publications with AVPR1A and Edema
 Liver Diseases Antibodies  >79 publications with AVPR1A and Liver Diseases

Organs/Tissues associated with anti-AVPR1A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2679 publications with AVPR1A and Brain
 Kidney Antibodies  >1440 publications with AVPR1A and Kidney
 Heart Antibodies  >959 publications with AVPR1A and Heart
 Muscle Antibodies  >641 publications with AVPR1A and Muscle
 Liver Antibodies  >501 publications with AVPR1A and Liver
 Adrenal Gland Antibodies  >283 publications with AVPR1A and Adrenal Gland
 Uterus Antibodies  >213 publications with AVPR1A and Uterus
 Parathyroid Antibodies  >71 publications with AVPR1A and Parathyroid
 Ganglia Antibodies  >58 publications with AVPR1A and Ganglia
 Intestine Antibodies  >51 publications with AVPR1A and Intestine
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