CLIC4 Antibody – Goat Polyclonal

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

CLIC4: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: actin cytoskeleton; apical part of cell; cell surface; centrosome; cytoplasm; cytoplasmic vesicle membrane; cytosol; intercellular junction; intracellular; microtubule cytoskeleton; microvillus; midbody; mitochondrion; nuclear matrix; perinuclear region of cytoplasm; plasma membrane

Molecular Function: chloride channel activity; glutathione transferase activity; protein binding; voltage-gated ion channel activity

Biological Process: angiogenesis; apoptosis; branching morphogenesis of a tube; cell differentiation; chloride transport; endothelial cell morphogenesis; establishment and/or maintenance of apical/basal cell polarity; fertilization; glutathione metabolic process; keratinocyte differentiation; multicellular organism growth; negative regulation of cell migration; regulation of cytoskeleton organization and biogenesis; vacuolar acidification