DPM2 Antibody – Goat Polyclonal

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]

DPM2: Regulates the biosynthesis of dolichol phosphate- mannose. Essential for the ER localization and stable expression of DPM1. Belongs to the DPM2 family.

Protein type: Transferase; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q34.13

Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral to endoplasmic reticulum membrane

Molecular Function: dolichyl-phosphate beta-D-mannosyltransferase activity; enzyme regulator activity; protein binding

Biological Process: dolichol metabolic process; GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; protein amino acid N-linked glycosylation via asparagine; protein amino acid O-linked mannosylation; regulation of catalytic activity; regulation of protein stability

Disease: Congenital Disorder Of Glycosylation, Type Iu