TNKS2 Antibody – Goat Polyclonal

TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Protein type: Nuclear envelope; Transferase; EC 2.4.2.30

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: cytoplasm; cytosol; Golgi membrane; nuclear chromosome, telomeric region; nuclear envelope; nucleus; pericentriolar material; perinuclear region of cytoplasm

Molecular Function: enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity; protein binding

Biological Process: multicellular organism growth; positive regulation of telomere maintenance via telomerase; protein amino acid ADP-ribosylation; protein polyubiquitination; regulation of multicellular organism growth; Wnt receptor signaling pathway