STK36 Antibody – Goat Polyclonal

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Fused: a serine/threonine protein kinase of the ULK family. Plays a role in Hedgehog (Hh) signaling. Interacts with Smoothened (Smo), the receptor for Hedgehog (Hh). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of Fused to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; Other group; ULK family

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytoplasm; nucleus

Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity; transcription factor binding

Biological Process: activation of hh target transcription factor; brain development; cilium biogenesis; positive regulation of smoothened signaling pathway; post-embryonic development; protein amino acid phosphorylation; regulation of transcription factor activity