HTR2A Antibody – Goat Polyclonal

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: axon; caveola; cell soma; cytoplasmic membrane-bound vesicle; cytosol; dendritic shaft; integral to plasma membrane; plasma membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; protein complex binding; serotonin binding; serotonin receptor activity; viral receptor activity

Biological Process: aging; artery smooth muscle contraction; behavioral response to cocaine; cell death; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; entry of virus into host cell; memory; negative regulation of potassium ion transport; negative regulation of synaptic transmission, glutamatergic; phosphoinositide 3-kinase cascade; phospholipase C activation; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of glycolysis; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of vasoconstriction; regulation of behavior; regulation of dopamine secretion; regulation of hormone secretion; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; sleep; synaptic transmission; thermoregulation; urinary bladder smooth muscle contraction

Disease: Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Major Depressive Disorder; Obsessive-compulsive Disorder; Schizophrenia