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UBR2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421764

MBS421764 is an antibody targeting UBR2. Also known as Goat anti-UBR2 Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UBR2, Polyclonal Antibody
Full Product Name
Goat anti-UBR2 Antibody
Product Gene Name
anti-UBR2 antibody
Product Synonym Names
UBR2; ubiquitin protein ligase E3 component n-recognin 2; C6orf133; DKFZp686C08114; KIAA0349; MGC71112; RP3-392M17.3; bA49A4.1; dJ242G1.1; dJ392M17.3; OTTHUMP00000016403; OTTHUMP00000016405; OTTHUMP00000039767; OTTHUMP00000039768; ubiquitin ligase E3 alph; UBR2 antibody; ubiquitin protein ligase E3 component n-recognin 2 antibody; C6orf133 antibody; DKFZp686C08114 antibody; KIAA0349 antibody; MGC71112 antibody; RP3-392M17.3 antibody; bA49A4.1 antibody; dJ242G1.1 antibody; dJ392M17.3 antibody; OTTHUMP00000016403 antibody; OTTHUMP00000016405 antibody; OTTHUMP00000039767 antibody; OTTHUMP00000039768 antibody; ubiquitin ligase E3 alpha-II antibody
Immunogen Sequence
SCPKSGGDKS RAPT
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
UBR2 peptide (MBS425808) is used for blocking the activity of UBR2 antibody (MBS421764)
Molecular Weight
200,540 Da
OMIM
609134
Immunogen
Peptide with sequence SCPKSGGDKSRAPT, from the internal region of the protein sequence according to NP_056070.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-UBR2 antibody
Peptide ELISA (EIA)
Application Notes for anti-UBR2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave bands at approx 150kDa in Rat Testis lysates after 0. 01ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 199kDa according to Rat NP_001171542.1. The detected band was successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Other Notes

Small volumes of anti-UBR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UBR2. It may not necessarily be applicable to this product.

NCBI GI #
27597061
NCBI GeneID
23304
NCBI Accession #
NP_056070.1
UniProt Secondary Accession #
O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0
UniProt Related Accession #
Q8IWV8
GenBank Nucleotide #
NM_015255.2
NCBI Official Full Name
E3 ubiquitin-protein ligase UBR2 isoform 1
NCBI Official Synonym Full Names
ubiquitin protein ligase E3 component n-recognin 2
NCBI Official Symbol
UBR2
NCBI Official Synonym Symbols
C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3
UniProt Protein Name
E3 ubiquitin-protein ligase UBR2
UniProt Synonym Protein Names
N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
UBR2
UniProt Synonym Gene Names
C6orf133; KIAA0349
UniProt Entry Name
UBR2_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase UBR2

NCBI Summary for UBR2

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UniProt Comments for UBR2

UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: chromatin; cytoplasm; cytosol; nucleoplasm; plasma membrane; ubiquitin ligase complex

Molecular Function: ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: chromatin silencing; histone H2A ubiquitination; male meiosis I; negative regulation of TOR signaling pathway; protein polyubiquitination; spermatogenesis
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Research Articles on UBR2

1. The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBR2 antibody

 Reference Product  PubMed Publications
 UBR4 antibody  >7 publications with UBR2 and UBR4
 UBE2A antibody  >2 publications with UBR2 and UBE2A
 UBE2B antibody  >2 publications with UBR2 and UBE2B
 ATE1 antibody  >1 publications with UBR2 and ATE1

Pathways associated with anti-UBR2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-UBR2 antibody

 Disease Name  Pubmed Publications
 Genital Diseases, Male Antibodies  >3 publications with UBR2 and Genital Diseases, Male
 Carcinoma Antibodies  >3 publications with UBR2 and Carcinoma
 Congenital Abnormalities Antibodies  >2 publications with UBR2 and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >1 publications with UBR2 and Cardiovascular Diseases
 Adenoma Antibodies  >1 publications with UBR2 and Adenoma
 Disease Models, Animal Antibodies  >1 publications with UBR2 and Disease Models, Animal
 Infertility, Female Antibodies  >1 publications with UBR2 and Infertility, Female
 Oligospermia Antibodies  >1 publications with UBR2 and Oligospermia
 Carcinoma, Hepatocellular Antibodies  >1 publications with UBR2 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >1 publications with UBR2 and Weight Loss

Organs/Tissues associated with anti-UBR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >7 publications with UBR2 and Muscle
 Testis Antibodies  >4 publications with UBR2 and Testis
 Blood Antibodies  >3 publications with UBR2 and Blood
 Lung Antibodies  >2 publications with UBR2 and Lung
 Heart Antibodies  >2 publications with UBR2 and Heart
 Vascular Antibodies  >1 publications with UBR2 and Vascular
 Liver Antibodies  >1 publications with UBR2 and Liver
 Eye Antibodies  >1 publications with UBR2 and Eye
 Embryonic Tissue Antibodies  >1 publications with UBR2 and Embryonic Tissue
 Bone Antibodies  >1 publications with UBR2 and Bone
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