• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IMPDH2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421769

MBS421769 is an antibody targeting IMPDH2. Also known as Goat anti-IMPDH2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IMPDH2, Polyclonal Antibody
Full Product Name
Goat anti-IMPDH2 Antibody
Product Gene Name
Product Synonym Names
IMPDH2; IMP (inosine monophosphate) dehydrogenase 2; IMPD2; IMPDH-II; IMP dehydrogenase 2; IMP oxireductase 2; inosine 5' phosphate dehydrogenase 2; inosine monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; inosine monophosphate; IMPDH2 antibody; IMP (inosine monophosphate) dehydrogenase 2 antibody; IMPD2 antibody; IMPDH-II antibody; IMP dehydrogenase 2 antibody; IMP oxireductase 2 antibody; inosine 5\1 phosphate dehydrogenase 2 antibody; inosine monophosphate dehydrogenase 2 antibody; inosine monophosphate dehydrogenase type II antibody; inosine monophosphate oxireductase 2 antibody
Immunogen Sequence
KEEEHDCFLE EI
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
IMPDH2 peptide (MBS425515) is used for blocking the activity of IMPDH2 antibody (MBS421769)
Molecular Weight
55,805 Da
OMIM
146691
Immunogen
Peptide with sequence KEEEHDCFLEEI, from the internal region of the protein sequence according to NP_000875.2.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-IMPDH2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-IMPDH2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx. 60kDa band observed in Human Skeletal Muscle lysates (calculated MW of 55.8kDa according to NP_000875.2). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-IMPDH2 antibody

(1ug/ml) staining of Human Skeletal Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-IMPDH2 Polyclonal Antibody – Cat# MBS421769

Other Notes

Small volumes of anti-IMPDH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
inosine-5'-monophosphate dehydrogenase 2
NCBI Official Synonym Full Names
IMP (inosine 5'-monophosphate) dehydrogenase 2
NCBI Official Symbol
IMPDH2
NCBI Official Synonym Symbols
IMPD2; IMPDH-II
UniProt Protein Name
Inosine-5'-monophosphate dehydrogenase 2
UniProt Synonym Protein Names
IMPDH-II
UniProt Gene Name
IMPDH2
UniProt Synonym Gene Names
IMP dehydrogenase 2; IMPD 2; IMPDH 2
UniProt Entry Name
IMDH2_HUMAN
NCBI Protein Information
inosine-5'-monophosphate dehydrogenase 2

NCBI Summary for IMPDH2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for IMPDH2

IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: EC 1.1.1.205; Nucleotide Metabolism - purine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: cytoplasm; cytosol; membrane; nucleus; peroxisomal membrane

Molecular Function: IMP dehydrogenase activity; nucleotide binding; protein binding

Biological Process: GTP biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000