GAL Antibody – Goat Polyclonal

This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]

Galanin: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. Belongs to the galanin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: cell soma; extracellular region; extracellular space; Golgi apparatus; secretory granule

Molecular Function: galanin receptor activity; neuropeptide hormone activity; protein binding; type 1 galanin receptor binding; type 2 galanin receptor binding; type 3 galanin receptor binding

Biological Process: cAMP-mediated signaling; feeding behavior; inflammatory response; insulin secretion; negative regulation of lymphocyte proliferation; nervous system development; neuropeptide signaling pathway; positive regulation of apoptosis; positive regulation of catagen; positive regulation of cortisol secretion; positive regulation of transcription from RNA polymerase II promoter; regulation of glucocorticoid metabolic process; response to drug; response to estrogen stimulus; response to insulin stimulus

Disease: Epilepsy, Familial Temporal Lobe, 8