PTGER3 Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

PTGER3: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p31.2

Cellular Component: brush border membrane; cell soma; cell surface; integral to membrane; integral to plasma membrane; nuclear envelope; nuclear membrane; plasma membrane

Molecular Function: ligand-dependent nuclear receptor activity; prostaglandin E receptor activity

Biological Process: cell death; elevation of cytosolic calcium ion concentration; female pregnancy; G-protein coupled receptor protein signaling pathway; intestine smooth muscle contraction; intracellular receptor-mediated signaling pathway; maternal process involved in parturition; negative regulation of cAMP biosynthetic process; negative regulation of insulin secretion; positive regulation of cAMP biosynthetic process; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of fever; positive regulation of vasoconstriction; response to drug; response to estradiol stimulus; response to progesterone stimulus; transcription, DNA-dependent; urinary bladder smooth muscle contraction