Goat Anti-ERN2 Polyclonal Antibody – Cat# MBS421807

ERN2 Antibody – Goat Polyclonal

Name: ERN2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421807
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421807

MBS421807 is an antibody targeting ERN2. Also known as Goat anti-ERN2/IRE1b Antibody. Reactive in Expected from sequence similarity: Human. Host: Goat. More details

$305 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ERN2/IRE1b, Polyclonal Antibody

Full Product Name

Goat anti-ERN2/IRE1b Antibody

Product Gene Name

anti-ERN2 antibody

Product Synonym Gene Name

IRE1b

Product Synonym Names

ERN2; endoplasmic reticulum to nucleus signaling 2; IRE1b; ER to nucleus signalling 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; endoplasmic reticulum to nucleus signalling 2; inositol-requiring 1 beta; ERN2 antibody; endoplasmic reticulum to nucleus signaling 2 antibody; IRE1b antibody; ER to nucleus signalling 2 antibody; IRE1 beta antibody; IRE1; S. cerevisiae; homolog of antibody; endoplasmic reticulum to nucleus signalling 2 antibody; inositol-requiring 1 beta antibody; ERN2 / IRE1b

Immunogen Sequence

QKRLQSPSKQ AQPLD

Clonality

Polyclonal

Host

Goat

Species Reactivity

Expected from sequence similarity: Human

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

ERN2 / IRE1b peptide (MBS426883) is used for blocking the activity of ERN2/IRE1b antibody (MBS421807)

Molecular Weight

102,480 Da

OMIM

604034

Immunogen

Peptide with sequence C-QKRLQSPSKQAQPLD, from the internal region of the protein sequence according to NP_150296.3.

Epitope

Internal region

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-ERN2 antibody

Peptide ELISA (EIA)

Application Notes for anti-ERN2 antibody

Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 37kDa band in Human Duodenum, Pancreas and Placenta lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 107kDa according to NP_150296.3. The 37kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-ERN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ERN2. It may not necessarily be applicable to this product.

NCBI GI #

145312265

NCBI GeneID

10595

NCBI Accession #

NP_150296.3

UniProt Secondary Accession #

Q6ZNC0

UniProt Related Accession #

Q76MJ5

GenBank Nucleotide #

NM_033266.3

NCBI Official Full Name

serine/threonine-protein kinase/endoribonuclease IRE2

NCBI Official Synonym Full Names

endoplasmic reticulum to nucleus signaling 2

NCBI Official Symbol

ERN2

NCBI Official Synonym Symbols

IRE1b; IRE2p; hIRE2p; IRE1-BETA

UniProt Protein Name

Serine/threonine-protein kinase/endoribonuclease IRE2

UniProt Synonym Protein Names

Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b

Protein Family

Serine/threonine-protein kinase/endoribonuclease

UniProt Gene Name

ERN2

UniProt Synonym Gene Names

hIRE2p; IRE1b

UniProt Entry Name

ERN2_HUMAN

NCBI Protein Information

serine/threonine-protein kinase/endoribonuclease IRE2

UniProt Comments for ERN2

IRE2: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein type: Membrane protein, integral; Ribonuclease; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Apoptosis; Other group; IRE family

Chromosomal Location of Human Ortholog: 16p12.2

Cellular Component: integral to membrane

Molecular Function: ATP binding; endonuclease activity; magnesium ion binding; protein serine/threonine kinase activity; ribonuclease activity

Biological Process: apoptotic chromosome condensation; mRNA processing; negative regulation of transcription, DNA-dependent; protein amino acid phosphorylation; rRNA catabolic process; transcription, DNA-dependent

Research Articles on ERN2

1. The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERN2 antibody

Reference Product	PubMed Publications
ATF6 antibody	>95 publications with ERN2 and ATF6
HSPA5 antibody	>8 publications with ERN2 and HSPA5
SYVN1 antibody	>2 publications with ERN2 and SYVN1
TMBIM6 antibody	>1 publications with ERN2 and TMBIM6
MTTP antibody	>1 publications with ERN2 and MTTP

Diseases associated with anti-ERN2 antibody

Disease Name	Pubmed Publications
Death Antibodies	>63 publications with ERN2 and Death
Inflammation Antibodies	>18 publications with ERN2 and Inflammation
Disease Models, Animal Antibodies	>18 publications with ERN2 and Disease Models, Animal
Necrosis Antibodies	>13 publications with ERN2 and Necrosis
Vascular Diseases Antibodies	>13 publications with ERN2 and Vascular Diseases
Immune System Diseases Antibodies	>9 publications with ERN2 and Immune System Diseases
Atherosclerosis Antibodies	>8 publications with ERN2 and Atherosclerosis
Insulin Resistance Antibodies	>7 publications with ERN2 and Insulin Resistance
Hyperinsulinism Antibodies	>6 publications with ERN2 and Hyperinsulinism
Kidney Diseases Antibodies	>5 publications with ERN2 and Kidney Diseases

Organs/Tissues associated with anti-ERN2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with ERN2 and Brain
Pancreas Antibodies	>17 publications with ERN2 and Pancreas
Kidney Antibodies	>9 publications with ERN2 and Kidney
Lung Antibodies	>6 publications with ERN2 and Lung
Intestine Antibodies	>6 publications with ERN2 and Intestine
Mouth Antibodies	>2 publications with ERN2 and Mouth
Prostate Antibodies	>1 publications with ERN2 and Prostate
Bladder Antibodies	>1 publications with ERN2 and Bladder