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SOCS7 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421810

MBS421810 is an antibody targeting SOCS7. Also known as Goat anti-SOCS7 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SOCS7, Polyclonal Antibody
Full Product Name
Goat anti-SOCS7 Antibody
Product Gene Name
anti-SOCS7 antibody
Product Synonym Names
SOCS7; suppressor of cytokine signaling 7; NAP4; Nck, Ash and phospholipase C binding protein; SOCS7 antibody; suppressor of cytokine signaling 7 antibody; NAP4 antibody; Nck; Ash and phospholipase C binding protein antibody
Immunogen Sequence
DAGRKPKLTR TQS
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
SOCS7 peptide (MBS425955) is used for blocking the activity of SOCS7 antibody (MBS421810)
Molecular Weight
37,461 Da
OMIM
608788
Immunogen
Peptide with sequence C-DAGRKPKLTRTQS, from the internal region of the protein sequence according to NP_055413.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SOCS7 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-SOCS7 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx. 60kDa band observed in lysates of Daudi (calculated MW of 63. 0kDa according to NP_055413.1). Recommended concentration: 1-3ug/ml. An additional band of unknown identity was also consistently observed at 28kDa. This band was successfully blocked by incubation with the immunizing peptide.

Western Blot (WB) of anti-SOCS7 antibody

(1ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SOCS7 Polyclonal Antibody – Cat# MBS421810

Other Notes

Small volumes of anti-SOCS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SOCS7. It may not necessarily be applicable to this product.

NCBI GI #
53831997
NCBI GeneID
30837
NCBI Accession #
NP_055413.1
UniProt Secondary Accession #
Q0IJ63; A2VCU2
UniProt Related Accession #
O14512
GenBank Nucleotide #
NM_014598.3
NCBI Official Full Name
suppressor of cytokine signaling 7
NCBI Official Synonym Full Names
suppressor of cytokine signaling 7
NCBI Official Symbol
SOCS7
NCBI Official Synonym Symbols
NAP4; NCKAP4
UniProt Protein Name
Suppressor of cytokine signaling 7
UniProt Synonym Protein Names
Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4
Protein Family
Suppressor of cytokine signaling
UniProt Gene Name
SOCS7
UniProt Synonym Gene Names
NAP4; SOCS6; SOCS-7; NAP-4
UniProt Entry Name
SOCS7_HUMAN
NCBI Protein Information
suppressor of cytokine signaling 7

UniProt Comments for SOCS7

SOCS7: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Inhibitor

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm; nucleus; plasma membrane

Molecular Function: protein binding; protein kinase inhibitor activity; SH3 domain binding

Biological Process: cytokine and chemokine mediated signaling pathway; fat cell differentiation; insulin receptor signaling pathway; layer formation in the cerebral cortex; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; protein ubiquitination; radial glia guided migration of Purkinje cell; regulation of growth
Show more

Research Articles on SOCS7

1. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SOCS7 antibody

 Products by Pathway  Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 JAK-STAT Signaling Pathway antibodies  JAK-STAT Signaling Pathway Diagram
 JAK-STAT Signaling Pathway antibodies  JAK-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram

Diseases associated with anti-SOCS7 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with SOCS7 and Inflammation
 Liver Diseases Antibodies  >5 publications with SOCS7 and Liver Diseases
 Nervous System Diseases Antibodies  >4 publications with SOCS7 and Nervous System Diseases
 Liver Neoplasms Antibodies  >3 publications with SOCS7 and Liver Neoplasms
 Necrosis Antibodies  >3 publications with SOCS7 and Necrosis
 Disease Models, Animal Antibodies  >1 publications with SOCS7 and Disease Models, Animal
 Fibrosis Antibodies  >1 publications with SOCS7 and Fibrosis
 Fatty Liver Antibodies  >1 publications with SOCS7 and Fatty Liver
 Hyperplasia Antibodies  >1 publications with SOCS7 and Hyperplasia

Organs/Tissues associated with anti-SOCS7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with SOCS7 and Blood
 Liver Antibodies  >8 publications with SOCS7 and Liver
 Muscle Antibodies  >4 publications with SOCS7 and Muscle
 Brain Antibodies  >4 publications with SOCS7 and Brain
 Lung Antibodies  >3 publications with SOCS7 and Lung
 Prostate Antibodies  >2 publications with SOCS7 and Prostate
 Mammary Gland Antibodies  >2 publications with SOCS7 and Mammary Gland
 Bone Antibodies  >2 publications with SOCS7 and Bone
 Embryonic Tissue Antibodies  >1 publications with SOCS7 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with SOCS7 and Pancreas
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