E2F7 Antibody – Goat Polyclonal

E2F7: Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Belongs to the E2F/DP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 12q21.2

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: identical protein binding; protein binding; transcription corepressor activity; transcription factor activity

Biological Process: DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of cell proliferation; negative regulation of cytokinesis; negative regulation of transcription from RNA polymerase II promoter; placenta development; positive regulation of DNA endoreduplication; positive regulation of transcription from RNA polymerase II promoter; sprouting angiogenesis; transcription, DNA-dependent