CXXC4 Antibody – Goat Polyclonal

This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CXXC4: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytoplasm; cytoplasmic vesicle

Molecular Function: DNA binding; PDZ domain binding; zinc ion binding

Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; zygotic determination of dorsal/ventral axis