Goat Anti-CYFIP1 Polyclonal Antibody – Cat# MBS421884

CYFIP1 Antibody – Goat Polyclonal

Name: CYFIP1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421884
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421884

MBS421884 is an antibody targeting CYFIP1. Also known as Goat anti-CYFIP1 Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CYFIP1, Polyclonal Antibody

Full Product Name

Goat anti-CYFIP1 Antibody

Product Gene Name

anti-CYFIP1 antibody

Product Synonym Names

CYFIP1; cytoplasmic FMR1 interacting protein 1; FLJ45151; P140SRA-1; SHYC; SRA1; cytoplasmic FMRP interacting protein 1; selective hybridizing clone; CYFIP1 antibody; cytoplasmic FMR1 interacting protein 1 antibody; FLJ45151 antibody; P140SRA-1 antibody; SHYC antibody; SRA1 antibody; cytoplasmic FMRP interacting protein 1 antibody; selective hybridizing clone antibody

Immunogen Sequence

TGSGRQEAQK TDAE

Clonality

Polyclonal

Host

Goat

Species Reactivity

Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

51,534 Da

OMIM

606322

Immunogen

Peptide with sequence C-TGSGRQEAQKTDAE, from the internal region of the protein sequence according to NP_055423.1.

Epitope

Internal region

Note

This antibody is expected to recognize isoform a (NP_055423.1) only.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CYFIP1 antibody

Peptide ELISA (EIA)

Application Notes for anti-CYFIP1 antibody

Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments in Human Kidney, Lung and Spleen lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).

Other Notes

Small volumes of anti-CYFIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYFIP1. It may not necessarily be applicable to this product.

NCBI GI #

24307969

NCBI GeneID

23191

NCBI Accession #

NP_055423.1

UniProt Secondary Accession #

Q14467; Q5IED0; Q6ZSX1; Q9BSD9; Q9BVC7; A8K6D9

UniProt Related Accession #

Q7L576

GenBank Nucleotide #

NM_014608.4

NCBI Official Full Name

cytoplasmic FMR1-interacting protein 1 isoform a

NCBI Official Synonym Full Names

cytoplasmic FMR1 interacting protein 1

NCBI Official Symbol

CYFIP1

NCBI Official Synonym Symbols

SHYC; SRA1; SRA-1; P140SRA-1

UniProt Protein Name

Cytoplasmic FMR1-interacting protein 1

UniProt Synonym Protein Names

Specifically Rac1-associated protein 1; Sra-1; p140sra-1

Protein Family

Cytoplasmic FMR1-interacting protein

UniProt Gene Name

CYFIP1

UniProt Synonym Gene Names

Sra-1

UniProt Entry Name

CYFP1_HUMAN

NCBI Protein Information

cytoplasmic FMR1-interacting protein 1

UniProt Comments for CYFIP1

CYFIP1: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. Belongs to the CYFIP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15q11

Cellular Component: cytosol; focal adhesion; lamellipodium; mRNA cap complex; neuron projection; perinuclear region of cytoplasm; ruffle; synapse

Molecular Function: actin filament binding; protein binding; protein complex binding; Rac GTPase binding

Biological Process: axon extension; cognition; lamellipodium biogenesis; Rac protein signal transduction; regulation of cell shape; ruffle organization and biogenesis; vascular endothelial growth factor receptor signaling pathway

Research Articles on CYFIP1

1. This study confirmed that CYFIP2 were altered in postsynaptic density in patient with schizophrenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYFIP1 antibody

Reference Product	PubMed Publications
FMR1 antibody	>18 publications with CYFIP1 and FMR1
RAC1 antibody	>12 publications with CYFIP1 and RAC1
EIF4E antibody	>9 publications with CYFIP1 and EIF4E
NCKAP1 antibody	>3 publications with CYFIP1 and NCKAP1
FXR2 antibody	>2 publications with CYFIP1 and FXR2
WASF2 antibody	>2 publications with CYFIP1 and WASF2
BRK1 antibody	>2 publications with CYFIP1 and BRK1
WASF1 antibody	>2 publications with CYFIP1 and WASF1
ABI2 antibody	>1 publications with CYFIP1 and ABI2

Pathways associated with anti-CYFIP1 antibody

Products by Pathway	Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies	Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
RHO GTPase Effectors Pathway antibodies	RHO GTPase Effectors Pathway Diagram
RHO GTPases Activate WASPs And WAVEs Pathway antibodies	RHO GTPases Activate WASPs And WAVEs Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
Regulation Of Actin Cytoskeleton Pathway antibodies	Regulation Of Actin Cytoskeleton Pathway Diagram
Regulation Of Actin Cytoskeleton Pathway antibodies	Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with anti-CYFIP1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>22 publications with CYFIP1 and Nervous System Diseases
Neurobehavioral Manifestations Antibodies	>21 publications with CYFIP1 and Neurobehavioral Manifestations
Learning Disorders Antibodies	>5 publications with CYFIP1 and Learning Disorders
Cognition Disorders Antibodies	>4 publications with CYFIP1 and Cognition Disorders
Cardiovascular Diseases Antibodies	>3 publications with CYFIP1 and Cardiovascular Diseases
Ataxia Antibodies	>3 publications with CYFIP1 and Ataxia
Heart Diseases Antibodies	>3 publications with CYFIP1 and Heart Diseases
Heart Defects, Congenital Antibodies	>2 publications with CYFIP1 and Heart Defects, Congenital
Cardiovascular Abnormalities Antibodies	>2 publications with CYFIP1 and Cardiovascular Abnormalities
Disease Models, Animal Antibodies	>2 publications with CYFIP1 and Disease Models, Animal

Organs/Tissues associated with anti-CYFIP1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with CYFIP1 and Brain
Nerve Antibodies	>15 publications with CYFIP1 and Nerve
Blood Antibodies	>5 publications with CYFIP1 and Blood
Heart Antibodies	>4 publications with CYFIP1 and Heart
Embryonic Tissue Antibodies	>3 publications with CYFIP1 and Embryonic Tissue
Eye Antibodies	>2 publications with CYFIP1 and Eye
Kidney Antibodies	>2 publications with CYFIP1 and Kidney
Bone Marrow Antibodies	>1 publications with CYFIP1 and Bone Marrow
Bone Antibodies	>1 publications with CYFIP1 and Bone
Prostate Antibodies	>1 publications with CYFIP1 and Prostate