TGFBR3 Antibody – Goat Polyclonal

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: cell surface; cytoplasm; external side of plasma membrane; extracellular space; integral to plasma membrane; proteinaceous extracellular matrix; receptor complex

Molecular Function: activin binding; coreceptor activity; fibroblast growth factor binding; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; punt binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cell growth; cell migration; epithelial to mesenchymal transition; heart morphogenesis; immune response; liver development; negative regulation of cell motility; negative regulation of epithelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; organ regeneration; palate development; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to follicle-stimulating hormone stimulus; response to hypoxia; transforming growth factor beta receptor complex assembly; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis