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Serotonin Receptor 3b/HTR3B (HTR3B) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421909

MBS421909 is an antibody targeting HTR3B. Also known as Goat anti-Serotonin Receptor 3B/HTR3B Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Serotonin Receptor 3B/HTR3B, Polyclonal Antibody
Full Product Name
Goat anti-Serotonin Receptor 3B/HTR3B Antibody
Product Gene Name
anti-HTR3B antibody
Product Synonym Names
HTR3B; 5-hydroxytryptamine (serotonin) receptor 3B; 5-HT3B; 5-hydroxytryptamine 3 receptor B subunit; serotonin-gated ion channel subunit; HTR3B antibody; 5-hydroxytryptamine (serotonin) receptor 3B antibody; 5-HT3B antibody; 5-hydroxytryptamine 3 receptor B subunit antibody; serotonin-gated ion channel subunit antibody; Serotonin Receptor 3B; Serotonin Receptor 3B / HTR3B
Immunogen Sequence
SNYLQTQDQT DQQE
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Serotonin Receptor 3B / HTR3B peptide (MBS425944) is used for blocking the activity of Serotonin Receptor 3B/HTR3B antibody (MBS421909)
Molecular Weight
49,285 Da
OMIM
604654
Immunogen
Peptide with sequence C-SNYLQTQDQTDQQE, from the internal region (near C-terminus) of the protein sequence according to NP_006019.1.
Epitope
Internal region (near C-Terminus)
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-HTR3B antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-HTR3B antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 51kDa band observed in Human Brain (Cerebral Cortex, Hippocampus and Amygdala) lysates (calculated MW of 50.3kDa according to NP_006019.1). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-HTR3B antibody

(1ug/ml) staining of Human Cerebral Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-HTR3B Polyclonal Antibody – Cat# MBS421909

Other Notes

Small volumes of anti-HTR3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HTR3B. It may not necessarily be applicable to this product.

NCBI GI #
5174469
NCBI GeneID
9177
NCBI Accession #
NP_006019.1
UniProt Secondary Accession #
Q0VJC3; B0YJ23
UniProt Related Accession #
O95264
GenBank Nucleotide #
NM_006028.4
NCBI Official Full Name
5-hydroxytryptamine receptor 3B
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 3B
NCBI Official Symbol
HTR3B
NCBI Official Synonym Symbols
5-HT3B
UniProt Protein Name
5-hydroxytryptamine receptor 3B
UniProt Synonym Protein Names
Serotonin receptor 3B
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR3B
UniProt Synonym Gene Names
5-HT3-B; 5-HT3B
UniProt Entry Name
5HT3B_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 3B

NCBI Summary for HTR3B

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
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UniProt Comments for HTR3B

5-HT(3B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, ion channel; Channel, cation; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cell surface; integral to plasma membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; serotonin receptor activity; serotonin-activated cation-selective channel activity

Biological Process: serotonin receptor signaling pathway; synaptic transmission; synaptic transmission, cholinergic; transport
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Research Articles on HTR3B

1. Study demonstrates that the 5-HT3Br1 transcriptional variant of the 5-HT3B subunit can contribute to the functional properties of heteromeric receptors in a similar manner to the originally characterized 5-HT3B subunit

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HTR3B antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-HTR3B antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >7 publications with HTR3B and Pain
 Nervous System Diseases Antibodies  >6 publications with HTR3B and Nervous System Diseases
 Depressive Disorder Antibodies  >3 publications with HTR3B and Depressive Disorder
 Anxiety Disorders Antibodies  >3 publications with HTR3B and Anxiety Disorders
 Muscular Diseases Antibodies  >3 publications with HTR3B and Muscular Diseases
 Disease Models, Animal Antibodies  >2 publications with HTR3B and Disease Models, Animal
 Cognition Disorders Antibodies  >2 publications with HTR3B and Cognition Disorders
 Memory Disorders Antibodies  >1 publications with HTR3B and Memory Disorders
 Hypertension Antibodies  >1 publications with HTR3B and Hypertension
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with HTR3B and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-HTR3B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with HTR3B and Brain
 Intestine Antibodies  >1 publications with HTR3B and Intestine
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