• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PGLYRP1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421952

MBS421952 is an antibody targeting PGLYRP1. Also known as Goat anti-PGRP-S Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PGRP-S (PGLYRP1), Polyclonal Antibody
Full Product Name
Goat anti-PGRP-S Antibody
Product Gene Name
anti-PGLYRP1 antibody
Product Synonym Gene Name
PGRP-S
Product Synonym Names
PGRP-S; PGRPS; PGLYRP1; peptidoglycan recognition protein 1; MGC126894; MGC126896; PGLYRP; PGRP; TAG7; TNFSF3L; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein); PGRP-S antibody; PGRPS antibody; PGLYRP1 antibody; peptidoglycan recognition protein 1 antibody; MGC126894 antibody; MGC126896 antibody; PGLYRP antibody; PGRP antibody; TAG7 antibody; TNFSF3L antibody; TNF superfamily; member 3 (LTB)-like (peptidoglycan recognition protein) antibody
Immunogen Sequence
PGNQLYHLIQ N
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
PGRP-S peptide (MBS425453) is used for blocking the activity of PGRP-S antibody (MBS421952)
Molecular Weight
21,731 Da
OMIM
604963
Immunogen
Peptide with sequence C-PGNQLYHLIQN, from the C Terminus of the protein sequence according to NP_005082.1.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-PGLYRP1 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PGLYRP1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Immunohistochemistry: In paraffin embedded Human Spleen shows staining of select splenocytes. Recommended concentration, 3-6ug/ml.
Western Blot: Approx 30kDa band observed in lysates of cell line Jurkat (calculated MW of 21.7kDa according to NP_005082.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Lu et al, J Biol Chem.2006 Mar 3;281(9): 5895-907; PMID: 16354652). Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-PGLYRP1 antibody

(0.3ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-PGLYRP1 Polyclonal Antibody – Cat# MBS421952

Immunohistochemistry (IHC) of anti-PGLYRP1 antibody

(3.8ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-PGLYRP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS421952

Other Notes

Small volumes of anti-PGLYRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PGLYRP1. It may not necessarily be applicable to this product.

NCBI GI #
4827036
NCBI GeneID
8993
NCBI Accession #
NP_005082.1
UniProt Secondary Accession #
Q4VB36
UniProt Related Accession #
O75594
GenBank Nucleotide #
NM_005091.2
NCBI Official Full Name
peptidoglycan recognition protein 1
NCBI Official Synonym Full Names
peptidoglycan recognition protein 1
NCBI Official Symbol
PGLYRP1
NCBI Official Synonym Symbols
PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
UniProt Protein Name
Peptidoglycan recognition protein 1
UniProt Synonym Protein Names
Peptidoglycan recognition protein short; PGRP-S
Protein Family
Peptidoglycan recognition protein
UniProt Gene Name
PGLYRP1
UniProt Synonym Gene Names
PGLYRP; PGRP; TNFSF3L; PGRP-S
UniProt Entry Name
PGRP1_HUMAN
NCBI Protein Information
peptidoglycan recognition protein 1

UniProt Comments for PGLYRP1

PGLYRP1: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Protein type: Secreted; Receptor, misc.; Apoptosis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: extracellular region

Molecular Function: N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding; peptidoglycan receptor activity; zinc ion binding

Biological Process: defense response to Gram-positive bacterium; detection of bacterium; immune response; innate immune response; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation during immune response; pattern recognition receptor signaling pathway; peptidoglycan catabolic process
Show more

Research Articles on PGLYRP1

1. Tag7, can bind to the TNFR1 receptor, thereby inhibiting the cytotoxic actions of the Tag7-Hsp70 complex and TNF-alpha, an acquired immunity cytokine.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PGLYRP1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with PGLYRP1 and Inflammation
 Necrosis Antibodies  >8 publications with PGLYRP1 and Necrosis
 Disease Models, Animal Antibodies  >7 publications with PGLYRP1 and Disease Models, Animal
 Immune System Diseases Antibodies  >6 publications with PGLYRP1 and Immune System Diseases
 Adenocarcinoma Antibodies  >3 publications with PGLYRP1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >2 publications with PGLYRP1 and Cardiovascular Diseases
 Metaplasia Antibodies  >2 publications with PGLYRP1 and Metaplasia
 Carcinoma Antibodies  >2 publications with PGLYRP1 and Carcinoma
 Lung Diseases Antibodies  >2 publications with PGLYRP1 and Lung Diseases
 Hyperplasia Antibodies  >2 publications with PGLYRP1 and Hyperplasia

Organs/Tissues associated with anti-PGLYRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with PGLYRP1 and Blood
 Bone Marrow Antibodies  >2 publications with PGLYRP1 and Bone Marrow
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000