PFKFB2 Antibody – Goat Polyclonal

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described.

Protein type: Carbohydrate Metabolism - fructose and mannose; Phosphatase (non-protein); EC 3.1.3.46; Motility/polarity/chemotaxis; Kinase, other; EC 2.7.1.105

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytosol

Molecular Function: 6-phosphofructo-2-kinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity; protein binding; protein kinase binding

Biological Process: carbohydrate phosphorylation; dephosphorylation; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; glycolysis; lactate metabolic process; positive regulation of glucokinase activity; positive regulation of insulin secretion; response to glucose stimulus