GRM7 Antibody – Goat Polyclonal

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; integral to membrane; integral to plasma membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane; receptor complex

Molecular Function: calcium channel regulator activity; calcium ion binding; glutamate binding; glutamate receptor activity; group III metabotropic glutamate receptor activity; PDZ domain binding; voltage-gated calcium channel activity

Biological Process: adult behavior; behavioral fear response; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of glutamate secretion; regulation of cyclase activity; regulation of synaptic transmission, glutamatergic; sensory perception of smell; sensory perception of sound; short-term memory; synaptic transmission; transmission of nerve impulse