MTNR1B Antibody – Goat Polyclonal

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1B: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 11q21-q22

Cellular Component: cytosol; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; melatonin receptor activity; protein binding

Biological Process: camera-type eye development; cell surface receptor linked signal transduction; circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; negative regulation of cGMP metabolic process; negative regulation of insulin secretion; negative regulation of neuron apoptosis; negative regulation of transmission of nerve impulse; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of transmission of nerve impulse; positive regulation of vasodilation; reduction of cytosolic calcium ion concentration; regulation of insulin secretion; synaptic transmission

Disease: Diabetes Mellitus, Noninsulin-dependent