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HTR7 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422059

MBS422059 is an antibody targeting HTR7. Also known as Goat anti-HTR7/5-HT7 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HTR7/5-HT7, Polyclonal Antibody
Full Product Name
Goat anti-HTR7/5-HT7 Antibody
Product Gene Name
anti-HTR7 antibody
Product Synonym Gene Name
5-HT7
Product Synonym Names
HTR7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-HT7; 5-hydroxytryptamine receptor 7; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; serotonin 5-HT-7 receptor; HTR7 antibody; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) antibody; 5-HT7 antibody; 5-hydroxytryptamine receptor 7 antibody; OTTHUMP00000020077 antibody; OTTHUMP00000020078 antibody; OTTHUMP00000020079 antibody; serotonin 5-HT-7 receptor antibody; HTR7 / 5-HT7
Immunogen Sequence
QNADYCRKKG HDS
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
HTR7 / 5-HT7 peptide (MBS426039) is used for blocking the activity of HTR7/5-HT7 antibody (MBS422059)
Molecular Weight
47,984 Da
OMIM
182137
Immunogen
Peptide with sequence QNADYCRKKGHDS, from the C Terminus of the protein sequence according to NP_000863.1.
Epitope
C Terminus
Note
This antibody is expected to recognize isoform a (NP_000863.1) only.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-HTR7 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-HTR7 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.

Western Blot (WB) of anti-HTR7 antibody

(1ug/ml) staining of KELLY lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-HTR7 Polyclonal Antibody – Cat# MBS422059

Other Notes

Small volumes of anti-HTR7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HTR7. It may not necessarily be applicable to this product.

NCBI GI #
4504547
NCBI GeneID
3363
NCBI Accession #
NP_000863.1
UniProt Secondary Accession #
P78336; P78372; P78516; Q5VX01; Q5VX02; Q5VX03; B5BUP6
UniProt Related Accession #
P34969
GenBank Nucleotide #
NM_000872.4
NCBI Official Full Name
5-hydroxytryptamine receptor 7 isoform a
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 7
NCBI Official Symbol
HTR7
NCBI Official Synonym Symbols
5-HT7
UniProt Protein Name
5-hydroxytryptamine receptor 7
UniProt Synonym Protein Names
5-HT-X; Serotonin receptor 7
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR7
UniProt Synonym Gene Names
5-HT-7; 5-HT7
UniProt Entry Name
5HT7R_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 7

NCBI Summary for HTR7

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
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UniProt Comments for HTR7

5-HT(7): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q21-q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: serotonin receptor activity

Biological Process: blood circulation; circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; serotonin receptor signaling pathway; smooth muscle contraction; synaptic transmission; vasoconstriction
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Research Articles on HTR7

1. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HTR7 antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram

Diseases associated with anti-HTR7 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >16 publications with HTR7 and Mental Disorders
 Nervous System Diseases Antibodies  >7 publications with HTR7 and Nervous System Diseases
 Schizophrenia Antibodies  >6 publications with HTR7 and Schizophrenia
 Inflammation Antibodies  >5 publications with HTR7 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with HTR7 and Disease Models, Animal
 Muscular Diseases Antibodies  >2 publications with HTR7 and Muscular Diseases
 Pain Antibodies  >2 publications with HTR7 and Pain
 Memory Disorders Antibodies  >2 publications with HTR7 and Memory Disorders
 Movement Disorders Antibodies  >1 publications with HTR7 and Movement Disorders
 Necrosis Antibodies  >1 publications with HTR7 and Necrosis

Organs/Tissues associated with anti-HTR7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with HTR7 and Brain
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