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KCNN2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422106

MBS422106 is an antibody targeting KCNN2. Also known as Goat anti-KCNN2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KCNN2, Polyclonal Antibody
Full Product Name
Goat anti-KCNN2 Antibody
Product Gene Name
anti-KCNN2 antibody
Product Synonym Names
KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; KCa2.2; SK2; SKCA2; hSK2; apamin-sensitive small-conductance Ca2+-activated potassium channel; small conductance calcium-activated potassium channel protein; KCNN2 antibody; potassium intermediate/small conductance calcium-activated channel; subfamily N; member 2 antibody; KCa2.2 antibody; SK2 antibody; SKCA2 antibody; hSK2 antibody; apamin-sensitive small-conductance Ca2+-activated potassium channel antibody; small conductance calcium-activated potassium channel protein 2 antibody
Immunogen Sequence
ESYDKHVTYN AER
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
KCNN2 peptide (MBS425445) is used for blocking the activity of KCNN2 antibody (MBS422106)
Molecular Weight
26,341 Da
OMIM
605879
Immunogen
Peptide with sequence C-ESYDKHVTYNAER, from the internal region of the protein sequence according to NP_067627.2; NP_740721.1.
Epitope
Internal region
Note
This antibody is expected to recognize both isoforms (NP_067627.2; NP_740721.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-KCNN2 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KCNN2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Humam Thyroid Gland shows membranous staining in the epithelial cells. Recommended concentration, 1-2ug/ml.
Western Blot: Approx 70kDa and 23kDa bands observed in Human Liver lysates (calculated MW of 63.8kDa according to NP_067627.2 and of 26.3kDa according to NP_740721.1). Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-KCNN2 antibody

(0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-KCNN2 Polyclonal Antibody – Cat# MBS422106

Immunohistochemistry (IHC) of anti-KCNN2 antibody

(3.8ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-KCNN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS422106

Other Notes

Small volumes of anti-KCNN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNN2. It may not necessarily be applicable to this product.

NCBI GI #
25777645
NCBI GeneID
3781
NCBI Accession #
NP_067627.2
NCBI Related Accession #
NP_740721.1
UniProt Secondary Accession #
Q0VFZ4; Q6PJI0; Q6X2Y2; A6NF94
UniProt Related Accession #
Q9H2S1
GenBank Nucleotide #
NM_021614.3
NCBI Official Full Name
small conductance calcium-activated potassium channel protein 2 isoform a
NCBI Official Synonym Full Names
potassium calcium-activated channel subfamily N member 2
NCBI Official Symbol
KCNN2
NCBI Official Synonym Symbols
SK2; hSK2; SKCA2; KCa2.2; SKCa 2
UniProt Protein Name
Small conductance calcium-activated potassium channel protein 2
UniProt Synonym Protein Names
KCa2.2
Protein Family
Small conductance calcium-activated potassium channel protein
UniProt Gene Name
KCNN2
UniProt Synonym Gene Names
SK2; SKCa 2; SKCa2
UniProt Entry Name
KCNN2_HUMAN
NCBI Protein Information
small conductance calcium-activated potassium channel protein 2

NCBI Summary for KCNN2

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
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UniProt Comments for KCNN2

KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q22.3

Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z disc

Molecular Function: alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activity

Biological Process: potassium ion transport
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Research Articles on KCNN2

1. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KCNN2 antibody

 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram

Diseases associated with anti-KCNN2 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >14 publications with KCNN2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >9 publications with KCNN2 and Arrhythmias, Cardiac
 Disease Models, Animal Antibodies  >6 publications with KCNN2 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >4 publications with KCNN2 and Neurobehavioral Manifestations
 Inflammation Antibodies  >3 publications with KCNN2 and Inflammation
 Learning Disorders Antibodies  >2 publications with KCNN2 and Learning Disorders
 Mental Disorders Antibodies  >2 publications with KCNN2 and Mental Disorders
 Pain Antibodies  >2 publications with KCNN2 and Pain
 Seizures Antibodies  >2 publications with KCNN2 and Seizures
 Fibrosis Antibodies  >1 publications with KCNN2 and Fibrosis

Organs/Tissues associated with anti-KCNN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >53 publications with KCNN2 and Brain
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