MTNR1A Antibody – Goat Polyclonal

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: cell soma; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: hormone binding; melatonin receptor activity; protein binding

Biological Process: aging; camera-type eye development; cell surface receptor linked signal transduction; circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; mating behavior; negative regulation of insulin secretion; positive regulation of cGMP biosynthetic process