• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TRPC7 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422153

MBS422153 is an antibody targeting TRPC7. Also known as Goat anti-TRPC7 Antibody. Reactive in Tested: Chicken; Expected from sequence similarity: Human, Mouse, Rat, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRPC7, Polyclonal Antibody
Full Product Name
Goat anti-TRPC7 Antibody
Product Gene Name
anti-TRPC7 antibody
Product Synonym Names
TRPC7; transient receptor potential cation channel, subfamily C, member 7; TRP7; likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7; putative capacitative calcium channel; TRPC7 antibody; transient receptor potential cation channel; subfamily C; member 7 antibody; TRP7 antibody; likley ortholog of mouse transient receptor potential cation channel; subfamily C; member 7 antibody; putative capacitative calcium channel antibody
Immunogen Sequence
KLCKSKAKSC END
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Chicken; Expected from sequence similarity: Human, Mouse, Rat, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
TRPC7 peptide (MBS425509) is used for blocking the activity of TRPC7 antibody (MBS422153)
Molecular Weight
92,429 Da
Immunogen
Peptide with sequence KLCKSKAKSCEND, from the internal region of the protein sequence according to NP_065122.1; NP_001161049.1; NP_001161048.1.
Epitope
Internal region
Note
This antibody is expected to cross-react with isoform 1, 2 and 3 (NP_065122.1; NP_001161049.1; NP_001161048.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TRPC7 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-TRPC7 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: A 95kDa band has been observed in Chicken Embryo Heart lysates in the following paper: Sabourin et al, Cardiovasc Res.2011 Jun 13, PMID 21672930.
Immunoprecipitation: This antibody has been successfully used in IP on lysates of Chicken Embryo Heart (PMID: 21672930).

Other Notes

Small volumes of anti-TRPC7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPC7. It may not necessarily be applicable to this product.

NCBI GI #
9966865
NCBI GeneID
57113
NCBI Accession #
NP_065122.1
NCBI Related Accession #
NP_001161049.1; NP_001161048.1
UniProt Secondary Accession #
Q70T26; Q8IWP7; A1A4Z4; F5H5U9
UniProt Related Accession #
Q9HCX4
GenBank Nucleotide #
NM_020389.2
NCBI Official Full Name
short transient receptor potential channel 7 isoform 1
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily C member 7
NCBI Official Symbol
TRPC7
NCBI Official Synonym Symbols
TRP7
UniProt Protein Name
Short transient receptor potential channel 7
UniProt Synonym Protein Names
Transient receptor protein 7; TRP-7; hTRP7
Protein Family
Short transient receptor potential channel
UniProt Gene Name
TRPC7
UniProt Synonym Gene Names
TRP7; TrpC7; TRP-7; hTRP7
UniProt Entry Name
TRPC7_HUMAN
NCBI Protein Information
short transient receptor potential channel 7

UniProt Comments for TRPC7

TRPC7: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cis-Golgi network; integral to plasma membrane; nuclear envelope; perinuclear region of cytoplasm; plasma membrane

Molecular Function: calcium channel activity; protein binding; store-operated calcium channel activity

Biological Process: cytosolic calcium ion homeostasis; manganese ion transport; platelet activation; single fertilization
Show more

Research Articles on TRPC7

1. A fundamental role for PI(4,5)P2 was identified in the regulation of TRPC7 and TRPC6.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TRPC7 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Netrin-1 Signaling Pathway antibodies  Netrin-1 Signaling Pathway Diagram

Diseases associated with anti-TRPC7 antibody

 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >7 publications with TRPC7 and Hypertrophy
 Edema Antibodies  >2 publications with TRPC7 and Edema
 Neurologic Manifestations Antibodies  >1 publications with TRPC7 and Neurologic Manifestations
 Breast Neoplasms Antibodies  >1 publications with TRPC7 and Breast Neoplasms
 Depressive Disorder Antibodies  >1 publications with TRPC7 and Depressive Disorder
 Kidney Diseases Antibodies  >1 publications with TRPC7 and Kidney Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with TRPC7 and Pancreatic Neoplasms
 Hyperplasia Antibodies  >1 publications with TRPC7 and Hyperplasia
 Inflammation Antibodies  >1 publications with TRPC7 and Inflammation

Organs/Tissues associated with anti-TRPC7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with TRPC7 and Brain
 Pancreas Antibodies  >1 publications with TRPC7 and Pancreas
 Testis Antibodies  >1 publications with TRPC7 and Testis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000