P2X4/P2X4R (P2RX4) Antibody – Goat Polyclonal

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.32

Cellular Component: cell junction; cell soma; dendritic spine; integral to nuclear inner membrane; integral to plasma membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; terminal button

Molecular Function: ATP binding; ATP-gated cation channel activity; cadherin binding; copper ion binding; drug binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding; zinc ion binding

Biological Process: blood coagulation; endothelial cell activation; generation of action potential; membrane depolarization; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin secretion; protein homooligomerization; regulation of blood pressure; regulation of sodium ion transport; response to ATP; sensory perception of pain; signal transduction; tissue homeostasis; transport