TRIP6 Antibody – Goat Polyclonal

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

TRIP6: thyroid receptor interacting protein 6 specifically interacts with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13. Functions downstream of the activated LPA(2) receptor and is involved in cell adhesion and migration.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: cytoplasm; cytoskeleton; focal adhesion; interleukin-1 receptor complex; nucleus; plasma membrane

Molecular Function: interleukin-1 receptor binding; kinase binding; protein binding; thyroid hormone receptor binding; zinc ion binding

Biological Process: focal adhesion formation; positive regulation of cell migration; regulation of transcription, DNA-dependent; release of cytoplasmic sequestered NF-kappaB; transcription, DNA-dependent