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WFDC2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422349

MBS422349 is an antibody targeting WFDC2. Also known as Goat anti-WFDC2 (aa29-43) Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WFDC2, Polyclonal Antibody
Full Product Name
Goat anti-WFDC2 (aa29-43) Antibody
Product Gene Name
anti-WFDC2 antibody
Product Synonym Names
WFDC2; WAP four-disulfide core domain 2; EDDM4; HE4; MGC57529; WAP5; dJ461P17. 6; WAP domain containing protein HE4-V4; epididymal protein 4; epididymal secretory protein E4; epididymis-specific, whey-acidic protein type, four-disulfide core; major epididy; dJ461P17. 6 antibody; EDDM4 antibody; epididymal protein 4 antibody; epididymal secretory protein E4 antibody; epididymis-specific; whey-acidic protein type; four-disulfide core antibody; HE4 antibody; major epididy antibody; MGC57529 antibody; WAP domain containing protein HE4-V4 antibody; WAP four-disulfide core domain 2 antibody; WAP5 antibody; WFDC2 antibody; WFDC2 (aa29-43)
Immunogen Sequence
GAEKTGVCPE LQADQ
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
WFDC2 peptide (MBS427264) is used for blocking the activity of WFDC2 antibody (MBS422349)
Molecular Weight
11,043 Da
Immunogen
Peptide with sequence GAEKTGVCPELQADQ, from the internal region of the protein sequence according to NP_006094.3.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-WFDC2 antibody
Peptide ELISA (EIA), Western Blot (WB-Trf)
Application Notes for anti-WFDC2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: In transfected HEK293 transiently expressing full-length Human WFDC2 (myc and DYKDDDDK tagged), a band of approx.25kDa was observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-myc tag antibody. Recommended concentration, 0.2-1ug/ml.

Western Blot (WB) of anti-WFDC2 antibody

HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human WFDC2 with C-terminal MYC tag probed (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Goat Anti-WFDC2 Polyclonal Antibody – Cat# MBS422349

Other Notes

Small volumes of anti-WFDC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for WFDC2. It may not necessarily be applicable to this product.

NCBI GI #
56699495
NCBI GeneID
10406
NCBI Accession #
NP_006094.3
UniProt Secondary Accession #
Q6IB27; Q8WXV9; Q8WXW0; Q8WXW1; Q8WXW2; Q96KJ1; A2A2A5; A2A2A6; A6PVD5
UniProt Related Accession #
Q14508
GenBank Nucleotide #
NM_006103.3
NCBI Official Full Name
WAP four-disulfide core domain protein 2
NCBI Official Synonym Full Names
WAP four-disulfide core domain 2
NCBI Official Symbol
WFDC2
NCBI Official Synonym Symbols
HE4; WAP5; EDDM4; dJ461P17.6
UniProt Protein Name
WAP four-disulfide core domain protein 2
UniProt Synonym Protein Names
Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5
Protein Family
WAP four-disulfide core domain protein
UniProt Gene Name
WFDC2
UniProt Synonym Gene Names
HE4; WAP5
UniProt Entry Name
WFDC2_HUMAN
NCBI Protein Information
WAP four-disulfide core domain protein 2

NCBI Summary for WFDC2

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
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UniProt Comments for WFDC2

WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space

Molecular Function: aspartic-type endopeptidase inhibitor activity; cysteine protease inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: proteolysis; spermatogenesis
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Research Articles on WFDC2

1. High serum HE4 level at diagnosis is an independent determinant of poor prognosis in NSCLC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WFDC2 antibody

 Reference Product  PubMed Publications
 SLPI antibody  >9 publications with WFDC2 and SLPI
 EGFR antibody  >7 publications with WFDC2 and EGFR
 MUC1 antibody  >2 publications with WFDC2 and MUC1
 MSLN antibody  >2 publications with WFDC2 and MSLN

Diseases associated with anti-WFDC2 antibody

 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >158 publications with WFDC2 and Ovarian Neoplasms
 Carcinoma Antibodies  >53 publications with WFDC2 and Carcinoma
 Adenocarcinoma Antibodies  >31 publications with WFDC2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >17 publications with WFDC2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >11 publications with WFDC2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >9 publications with WFDC2 and Breast Neoplasms
 Kidney Diseases Antibodies  >5 publications with WFDC2 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >5 publications with WFDC2 and Neoplasms, Experimental
 Fibrosis Antibodies  >3 publications with WFDC2 and Fibrosis
 Inflammation Antibodies  >3 publications with WFDC2 and Inflammation

Organs/Tissues associated with anti-WFDC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Epididymis Antibodies  >113 publications with WFDC2 and Epididymis
 Lung Antibodies  >17 publications with WFDC2 and Lung
 Ovary Antibodies  >17 publications with WFDC2 and Ovary
 Kidney Antibodies  >7 publications with WFDC2 and Kidney
 Uterus Antibodies  >7 publications with WFDC2 and Uterus
 Prostate Antibodies  >4 publications with WFDC2 and Prostate
 Muscle Antibodies  >3 publications with WFDC2 and Muscle
 Trachea Antibodies  >3 publications with WFDC2 and Trachea
 Heart Antibodies  >2 publications with WFDC2 and Heart
 Mammary Gland Antibodies  >2 publications with WFDC2 and Mammary Gland
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