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Spondin 2/Mindin (SPON2) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422350

MBS422350 is an antibody targeting SPON2. Also known as Goat anti-Spondin 2/Mindin Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow. Host: Goat. More details

$305 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Spondin 2/Mindin (SPON2), Polyclonal Antibody
Full Product Name
Goat anti-Spondin 2/Mindin Antibody
Product Gene Name
anti-SPON2 antibody
Product Synonym Names
Goat Anti-SPON2 (301-315) Antibody; SPON2; spondin 2, extracellular matrix protein; DIL-1; DIL1; M-spondin; Mindin; DIL1 antibody; DIL-1 antibody; Mindin antibody; M-spondin antibody; spondin 2; extracellular matrix protein antibody; SPON2 antibody; Spondin 2; Mindin; Spondin 2 / Mindin
Immunogen Sequence
RKNQYVSNGL RDFA
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Spondin 2 / Mindin peptide (MBS428083) is used for blocking the activity of Spondin 2/Mindin antibody (MBS422350)
Molecular Weight
35,846 Da
OMIM
605918
Immunogen
Peptide with sequence C-RKNQYVSNGLRDFA, from the internal region of the protein sequence according to NP_036577.1.
Epitope
Internal region
Note
Reported variants NP_036577.1 and NP_001121797.1 represent identical protein.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SPON2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-SPON2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 35kDa band observed in Human Prostate lysates (calculated MW of 35.8kDa according to NP_036577.1). Recommended concentration: 0.5-1.5ug/ml.

Western Blot (WB) of anti-SPON2 antibody

(1ug/ml) staining of Human Prostate lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SPON2 Polyclonal Antibody – Cat# MBS422350

Other Notes

Small volumes of anti-SPON2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPON2. It may not necessarily be applicable to this product.

NCBI GI #
6912682
NCBI GeneID
10417
NCBI Accession #
NP_036577.1
UniProt Secondary Accession #
Q4W5N4; Q9ULW1; D3DVN9
UniProt Related Accession #
Q9BUD6
GenBank Nucleotide #
NM_012445.3
NCBI Official Full Name
spondin-2
NCBI Official Synonym Full Names
spondin 2
NCBI Official Symbol
SPON2
NCBI Official Synonym Symbols
DIL1; DIL-1; MINDIN; M-SPONDIN
UniProt Protein Name
Spondin-2
UniProt Synonym Protein Names
Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin
Protein Family
Spondin
UniProt Gene Name
SPON2
UniProt Synonym Gene Names
DIL1; DIL-1
UniProt Entry Name
SPON2_HUMAN
NCBI Protein Information
spondin-2

UniProt Comments for SPON2

SPON2: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens. Binds bacterial lipopolysaccharide (LPS).

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: extracellular space; proteinaceous extracellular matrix

Molecular Function: antigen binding; lipopolysaccharide binding; metal ion binding; protein binding

Biological Process: axon guidance; cell adhesion; defense response to fungus; defense response to virus; induction of bacterial agglutination; innate immune response; mast cell mediated immunity; opsonization; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production
Show more

Research Articles on SPON2

1. Data suggest that spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SPON2 antibody

 Products by Pathway  Pathway Diagram
 Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway antibodies  Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With O-glycosylation Of Proteins Pathway antibodies  Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
 Diseases Of Glycosylation Pathway antibodies  Diseases Of Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram

Diseases associated with anti-SPON2 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >7 publications with SPON2 and Prostatic Neoplasms
 Necrosis Antibodies  >2 publications with SPON2 and Necrosis
 Liver Diseases Antibodies  >1 publications with SPON2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >1 publications with SPON2 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with SPON2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with SPON2 and Liver Neoplasms
 Lung Neoplasms Antibodies  >1 publications with SPON2 and Lung Neoplasms
 Fibrosis Antibodies  >1 publications with SPON2 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with SPON2 and Kidney Diseases
 Inflammation Antibodies  >1 publications with SPON2 and Inflammation

Organs/Tissues associated with anti-SPON2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with SPON2 and Blood
 Liver Antibodies  >2 publications with SPON2 and Liver
 Lung Antibodies  >1 publications with SPON2 and Lung
 Brain Antibodies  >1 publications with SPON2 and Brain
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