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ALDH6A1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422487

MBS422487 is an antibody targeting ALDH6A1. Also known as Goat anti-ALDH6A1 (aa262-272) Antibody. Reactive in Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ALDH6A1, Polyclonal Antibody
Full Product Name
Goat anti-ALDH6A1 (aa262-272) Antibody
Product Gene Name
anti-ALDH6A1 antibody
Product Synonym Names
Goat Anti-ALDH6A1 (aa487-496) Antibody; ALDH6A1; aldehyde dehydrogenase 6 family, member A1; MGC40271; MMSADHA; MMSDH; aldehyde dehydrogenase 6A1; mitochondrial acylating methylmalonate-semialdehyde dehydrogenase; aldehyde dehydrogenase 6 family; member A1 antibody; aldehyde dehydrogenase 6A1 antibody; MGC40271 antibody; mitochondrial acylating methylmalonate-semialdehyde dehydrogenase antibody; MMSADHA antibody; MMSDH antibody; ALDH6A1 antibody; ALDH6A1 (aa262-272)
Immunogen Sequence
SNKAGEYIFE R
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
ALDH6A1 peptide (MBS427723) is used for blocking the activity of ALDH6A1 antibody (MBS422487)
Molecular Weight
56,228 Da
OMIM
603178
Immunogen
Peptide with sequence C-SNKAGEYIFER, from the internal region of the protein sequence according to NP_005580.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-ALDH6A1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ALDH6A1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 55kDa band observed in Human, Mouse and Rat Kidney lysates (calculated MW of 57.8kDa according to NP_005580.1). Recommended concentration: 0.1-0.3ug/ml.

Western Blot (WB) of anti-ALDH6A1 antibody

(0.1ug/ml) staining of Mouse Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-ALDH6A1 Polyclonal Antibody – Cat# MBS422487

Other Notes

Small volumes of anti-ALDH6A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH6A1. It may not necessarily be applicable to this product.

NCBI GI #
11095441
NCBI GeneID
4329
NCBI Accession #
NP_005580.1
UniProt Secondary Accession #
Q9UKM8; B2R609; B4DFS8; J3KNU8
UniProt Related Accession #
Q02252
GenBank Nucleotide #
NM_005589.3
NCBI Official Full Name
methylmalonate-semialdehyde dehydrogenase
NCBI Official Synonym Full Names
aldehyde dehydrogenase 6 family member A1
NCBI Official Symbol
ALDH6A1
NCBI Official Synonym Symbols
MMSDH; MMSADHA
UniProt Protein Name
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 6 member A1
UniProt Gene Name
ALDH6A1
UniProt Synonym Gene Names
MMSDH; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]
UniProt Entry Name
MMSA_HUMAN
NCBI Protein Information
methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

NCBI Summary for ALDH6A1

This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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UniProt Comments for ALDH6A1

ALDH6A1: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Defects in ALDH6A1 are the cause of methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD). This is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Belongs to the aldehyde dehydrogenase family.

Protein type: EC 1.2.1.27; EC 1.2.1.18; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - inositol phosphate; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: mitochondrial matrix; mitochondrion; nucleoplasm

Molecular Function: acyl-CoA binding; aldehyde dehydrogenase (NAD) activity; malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; thiolester hydrolase activity

Biological Process: beta-alanine catabolic process; branched chain family amino acid catabolic process; brown fat cell differentiation; thymine catabolic process; thymine metabolic process; valine catabolic process; valine metabolic process

Disease: Methylmalonate Semialdehyde Dehydrogenase Deficiency
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Research Articles on ALDH6A1

1. ACAT1, ACACA, ALDH6A1 and MTHFD1 represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ALDH6A1 antibody

 Products by Pathway  Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA antibodies  Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA Diagram
 Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA antibodies  Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with anti-ALDH6A1 antibody

 Disease Name  Pubmed Publications
 Amino Acid Metabolism, Inborn Errors Antibodies  >2 publications with ALDH6A1 and Amino Acid Metabolism, Inborn Errors
 Obesity Antibodies  >2 publications with ALDH6A1 and Obesity
 Hypertension Antibodies  >1 publications with ALDH6A1 and Hypertension
 Liver Diseases Antibodies  >1 publications with ALDH6A1 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with ALDH6A1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with ALDH6A1 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >1 publications with ALDH6A1 and Weight Loss
 Kidney Diseases Antibodies  >1 publications with ALDH6A1 and Kidney Diseases
 Fatty Liver Antibodies  >1 publications with ALDH6A1 and Fatty Liver

Organs/Tissues associated with anti-ALDH6A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with ALDH6A1 and Liver
 Brain Antibodies  >2 publications with ALDH6A1 and Brain
 Connective Tissue Antibodies  >1 publications with ALDH6A1 and Connective Tissue
 Vascular Antibodies  >1 publications with ALDH6A1 and Vascular
 Kidney Antibodies  >1 publications with ALDH6A1 and Kidney
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