Goat Anti-CDC2L6 Polyclonal Antibody – Cat# MBS422527

CDC2L6 Antibody – Goat Polyclonal

Name: CDC2L6 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS422527
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422527

MBS422527 is an antibody targeting CDC2L6. Also known as Goat anti-CDC2L6 Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDC2L6, Polyclonal Antibody

Full Product Name

Goat anti-CDC2L6 Antibody

Product Gene Name

anti-CDC2L6 antibody

Product Synonym Names

CDC2L6; cell division cycle 2-like 6 (CDK8-like); CDK11; KIAA1028; bA346C16.3; CDK8-like cyclin-dependent kinase; cyclin-dependent kinase (CDC2-like) 11; death-preventing kinase; bA346C16.3 antibody; CDK11 antibody; CDK8-like cyclin-dependent kinase antibody; cell division cycle 2-like 6 (CDK8-like) antibody; cyclin-dependent kinase (CDC2-like) 11 antibody; death-preventing kinase antibody; KIAA1028 antibody; CDC2L6 antibody

Immunogen Sequence

QYHPSHQAHR

Clonality

Polyclonal

Host

Goat

Species Reactivity

Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

CDC2L6 peptide (MBS427710) is used for blocking the activity of CDC2L6 antibody (MBS422527)

Molecular Weight

49,870 Da

OMIM

614720

Immunogen

Peptide with sequence C-QYHPSHQAHR, from the C Terminus of the protein sequence according to NP_055891.1.

Epitope

C Terminus

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CDC2L6 antibody

Peptide ELISA (EIA)

Application Notes for anti-CDC2L6 antibody

Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave bands at approx 45kDa and 20kDa in Rat Eye lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 56.6kDa according to Rat NP_001101104.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Other Notes

Small volumes of anti-CDC2L6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC2L6. It may not necessarily be applicable to this product.

NCBI GI #

30387611

NCBI GeneID

23097

NCBI Accession #

NP_055891.1

UniProt Secondary Accession #

Q5JQZ7; Q5JR00; Q8TC78; Q9UPX2

UniProt Related Accession #

Q9BWU1

GenBank Nucleotide #

NM_015076.4

NCBI Official Full Name

cyclin-dependent kinase 19 isoform 1

NCBI Official Synonym Full Names

cyclin-dependent kinase 19

NCBI Official Symbol

CDK19

NCBI Official Synonym Symbols

CDK11; CDC2L6; bA346C16.3

UniProt Protein Name

Cyclin-dependent kinase 19

UniProt Synonym Protein Names

CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase

UniProt Gene Name

CDK19

UniProt Synonym Gene Names

CDC2L6; CDK11; KIAA1028

UniProt Entry Name

CDK19_HUMAN

NCBI Protein Information

cyclin-dependent kinase 19

NCBI Summary for CDC2L6

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

UniProt Comments for CDC2L6

CDK19: a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. [provided by RefSeq, Jul 2008]

Protein type: EC 2.7.11.22; Kinase, protein; Cell cycle regulation; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK8 subfamily

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cytosol; nucleus

Molecular Function: ATP binding; cyclin-dependent protein kinase activity; enzyme binding

Biological Process: positive regulation of apoptosis; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell cycle

Research Articles on CDC2L6

1. Mediator-associated kinases CDK8 and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML) cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CDC2L6 antibody

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Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
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Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies	Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with anti-CDC2L6 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>3 publications with CDC2L6 and Breast Neoplasms
Immune System Diseases Antibodies	>2 publications with CDC2L6 and Immune System Diseases
Disease Models, Animal Antibodies	>2 publications with CDC2L6 and Disease Models, Animal
Congenital Abnormalities Antibodies	>1 publications with CDC2L6 and Congenital Abnormalities
Adenocarcinoma Antibodies	>1 publications with CDC2L6 and Adenocarcinoma
Neurobehavioral Manifestations Antibodies	>1 publications with CDC2L6 and Neurobehavioral Manifestations
Nervous System Diseases Antibodies	>1 publications with CDC2L6 and Nervous System Diseases
Inflammation Antibodies	>1 publications with CDC2L6 and Inflammation

Organs/Tissues associated with anti-CDC2L6 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>2 publications with CDC2L6 and Bone
Lymph Antibodies	>1 publications with CDC2L6 and Lymph
Connective Tissue Antibodies	>1 publications with CDC2L6 and Connective Tissue
Eye Antibodies	>1 publications with CDC2L6 and Eye
Lymph Node Antibodies	>1 publications with CDC2L6 and Lymph Node
Prostate Antibodies	>1 publications with CDC2L6 and Prostate
Brain Antibodies	>1 publications with CDC2L6 and Brain