NOX5 Antibody – Goat Polyclonal

This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NOX5: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 1.6.3.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane

Molecular Function: calcium ion binding; FAD binding; heme binding; hydrogen ion channel activity; NADP binding; protein binding; superoxide-generating NADPH oxidase activity

Biological Process: angiogenesis; apoptosis; cell proliferation; cytokine secretion; cytokinesis; endothelial cell proliferation; proton transport; regulation of fusion of sperm to egg plasma membrane; regulation of proton transport; response to reactive oxygen species; superoxide release