ABCC4 Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: basolateral plasma membrane; integral to membrane; membrane; plasma membrane; platelet dense granule membrane

Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

Biological Process: cilium biogenesis; platelet degranulation; prostaglandin secretion; transmembrane transport