CD28 Antibody – Goat Polyclonal

CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cell surface; cytosol; external side of plasma membrane; immunological synapse; integral to plasma membrane; plasma membrane

Molecular Function: coreceptor activity; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protease binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity

Biological Process: cell surface receptor linked signal transduction; cytokine biosynthetic process; humoral immune response; negative thymic T cell selection; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of alpha-beta T cell proliferation; positive regulation of inflammatory response to antigenic stimulus; positive regulation of interleukin-10 production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of isotype switching to IgG isotypes; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation; positive regulation of viral genome replication; regulation of defense response to virus by virus; regulation of phosphoinositide 3-kinase cascade; regulation of regulatory T cell differentiation; regulatory T cell differentiation; T cell costimulation; T cell receptor signaling pathway