RORC Antibody – Goat Polyclonal

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; oxysterol binding; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; zinc ion binding

Biological Process: circadian regulation of gene expression; intracellular receptor-mediated signaling pathway; lymph node development; Peyer's patch development; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; steroid hormone mediated signaling; T-helper cell differentiation; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process

Disease: Immunodeficiency 42