Synaptotagmin-2 (SYT2) Antibody – Goat Polyclonal

This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

SYT2: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. Belongs to the synaptotagmin family.

Protein type: Membrane protein, integral; Vesicle; Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cell junction; cytosol; integral to membrane; intracellular membrane-bound organelle; plasma membrane; synaptic vesicle membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; inositol 1,3,4,5 tetrakisphosphate binding; protein binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; synaptic vesicle endocytosis; vesicle fusion

Disease: Myasthenic Syndrome, Presynaptic, Congenital, With Or Without Motor Neuropathy