Sirtuin 3 (SIRT3) Antibody – Goat Polyclonal

SIRT3: a soluble mitochondrial NAD-dependent protein deacetylase. Can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase. Mitochondrial proteins are hyperacetylated in SIRT3-deficient mice, but not in SIRT4 or SIRT5 deficient mice. SIRT3-deficient mice have no obvious metabolic phenotype, and the process of adaptive thermogenesis is normal. Can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that participates in regulation of the citric acid cycle and the regeneration of antioxidants. Inhibited by nicotinamide, but not by trichostatin A. Its unprocessed form is enzymatically inactive. It is processed by mitochondrial processing peptidase (MPP) in the mitochondrial matrix to give an enzymatically active 28 kDa product.

Protein type: Deacetylase; Mitochondrial; EC 3.5.1.-

Cellular Component: cytoplasm; membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrion

Molecular Function: (3,5-dichlorophenylurea)acetate amidohydrolase activity; enzyme binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; indoleacetamide hydrolase activity; iprodione amidohydrolase activity; metal ion binding; N-acetylgalactosamine-6-phosphate deacetylase activity; N2-acetyl-L-lysine deacetylase activity; NAD binding; NAD-dependent histone deacetylase activity (H3-K14 specific); O-succinylbenzoate synthase activity; protein binding; protein N-terminal asparagine amidohydrolase activity; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; zinc ion binding

Biological Process: aerobic respiration; positive regulation of insulin secretion; protein amino acid deacetylation