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KLHDC8B Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422620

MBS422620 is an antibody targeting KLHDC8B. Also known as Goat anti-KLHDC8B Antibody. Reactive in Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KLHDC8B, Polyclonal Antibody
Full Product Name
Goat anti-KLHDC8B Antibody
Product Gene Name
Product Synonym Names
KLHDC8B; kelch domain containing 8B; FLJ11302; MGC35097; kelch domain-containing protein 8B; FLJ11302 antibody; kelch domain containing 8B antibody; kelch domain-containing protein 8B antibody; MGC35097 antibody; KLHDC8B antibody
Immunogen Sequence
TKLPRSLRMR DK
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
KLHDC8B peptide (MBS427464) is used for blocking the activity of KLHDC8B antibody (MBS422620)
Molecular Weight
37,676 Da
OMIM
236000
Immunogen
Peptide with sequence C-TKLPRSLRMRDK, from the internal region of the protein sequence according to NP_775817.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-KLHDC8B antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-KLHDC8B antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.

Western Blot (WB) of anti-KLHDC8B antibody

(0.5ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-KLHDC8B Polyclonal Antibody – Cat# MBS422620

Other Notes

Small volumes of anti-KLHDC8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLHDC8B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kelch domain-containing protein 8B
NCBI Official Synonym Full Names
kelch domain containing 8B
NCBI Official Symbol
KLHDC8B
NCBI Official Synonym Symbols
CHL
UniProt Protein Name
Kelch domain-containing protein 8B
UniProt Gene Name
KLHDC8B
UniProt Entry Name
KLD8B_HUMAN
NCBI Protein Information
kelch domain-containing protein 8B

NCBI Summary for KLHDC8B

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]

UniProt Comments for KLHDC8B

KLHDC8B: Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL). A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm

Disease: Leg, Absence Deformity Of, With Congenital Cataract
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-KLHDC8B antibody

Organs/Tissues associated with anti-KLHDC8B antibody

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