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ITIH4 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422630

MBS422630 is an antibody targeting Itih4. Also known as Goat anti-Itih4 (mouse) Antibody. Reactive in Tested: Rat; Expected from sequence similarity: Mouse, Rat. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Itih4, Polyclonal Antibody
Full Product Name
Goat anti-Itih4 (mouse) Antibody
Product Gene Name
anti-Itih4 antibody
Product Synonym Names
Itih4; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); H4P; IHRP; ITIHL1; PK120; ITI heavy chain H4; ITI-HC4; OTTMUSP00000032461; PK-120; gp120; inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor family heav; Itih4 antibody; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) antibody; H4P antibody; IHRP antibody; ITIHL1 antibody; PK120 antibody; ITI heavy chain H4 antibody; ITI-HC4 antibody; OTTMUSP00000032461 antibody; PK-120 antibody; gp120 antibody; inter-alpha-inhibitor heavy chain 4 antibody; inter-alpha-trypsin inhibitor family heavy chain-related protein antibody; inter-alpha-trypsin inhibitor heavy chain H4 antibody; inter-alpha-trypsin inhibitor; heavy chain-like; 1 antibody; inter-alpha-trypsin inhibitor; heavy chain-related protein antibody; plasma kallikrein sensitive glycoprotein 120 antibody; plasma kallikrein-sensitive glycoprotein 120 antibody; Itih4 (mouse)
Immunogen Sequence
KPEGQEQFQV AEKP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Rat; Expected from sequence similarity: Mouse, Rat
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Itih4 peptide (MBS427530) is used for blocking the activity of Itih4 antibody (MBS422630)
Molecular Weight
100,395 Da
Immunogen
Peptide with sequence C-KPEGQEQFQVAEKP, from the internal region of the protein sequence according to NP_061216.2; NP_001152771.1.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_002209.2; NP_001159921.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Itih4 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-Itih4 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 100kDa band observed in Rat Liver lysates (calculated MW of 104kDa according to Rat NP_062242.2). Recommended concentration: 0. 03-0.1ug/ml.

Western Blot (WB) of anti-Itih4 antibody

(0. 03ug/ml) staining of Rat Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-ITIH4 Polyclonal Antibody – Cat# MBS422630

Other Notes

Small volumes of anti-Itih4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Itih4. It may not necessarily be applicable to this product.

NCBI GI #
226531047
NCBI GeneID
16427
NCBI Accession #
NP_061216.2
NCBI Related Accession #
NP_001152771.1
UniProt Secondary Accession #
O54882; Q505P8; Q8C7G9; Q8C7K5; Q91W60; Q9DBK8
UniProt Related Accession #
A6X935
GenBank Nucleotide #
NM_018746.4
NCBI Official Full Name
inter alpha-trypsin inhibitor, heavy chain 4 isoform 1
NCBI Official Synonym Full Names
inter alpha-trypsin inhibitor, heavy chain 4
NCBI Official Symbol
Itih4
NCBI Official Synonym Symbols
Itih-4; PK-120; ITI-HC4
UniProt Protein Name
Inter alpha-trypsin inhibitor, heavy chain 4
Protein Family
Inter alpha-trypsin inhibitor
UniProt Gene Name
Itih4
UniProt Synonym Gene Names
ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4
UniProt Entry Name
ITIH4_MOUSE
NCBI Protein Information
inter alpha-trypsin inhibitor, heavy chain 4

NCBI Summary for Itih4

This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
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UniProt Comments for Itih4

ITIH4: May be involved in acute phase reactions. Belongs to the ITIH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: cytoplasm; extracellular region; plasma membrane

Molecular Function: calcium ion binding; hyaluronic acid binding; protease inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: acute-phase response; hyaluronan metabolic process; negative regulation of peptidase activity
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Research Articles on Itih4

1. role in liver development and regeneration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Itih4 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-Itih4 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with Itih4 and Inflammation
 Liver Diseases Antibodies  >7 publications with Itih4 and Liver Diseases
 Fibrosis Antibodies  >5 publications with Itih4 and Fibrosis
 Brain Diseases Antibodies  >5 publications with Itih4 and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with Itih4 and Carcinoma, Hepatocellular
 Lung Diseases Antibodies  >4 publications with Itih4 and Lung Diseases
 Liver Neoplasms Antibodies  >4 publications with Itih4 and Liver Neoplasms
 Colonic Neoplasms Antibodies  >4 publications with Itih4 and Colonic Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Itih4 and Cardiovascular Diseases
 Hypertension Antibodies  >3 publications with Itih4 and Hypertension

Organs/Tissues associated with anti-Itih4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >20 publications with Itih4 and Liver
 Lung Antibodies  >5 publications with Itih4 and Lung
 Pancreas Antibodies  >3 publications with Itih4 and Pancreas
 Skin Antibodies  >2 publications with Itih4 and Skin
 Uterus Antibodies  >1 publications with Itih4 and Uterus
 Embryonic Tissue Antibodies  >1 publications with Itih4 and Embryonic Tissue
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