Goat Anti-CACNB2 Polyclonal Antibody – Cat# MBS422636

(1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CACNB2 Antibody – Goat Polyclonal

Name: CACNB2 Antibody; Polyclonal; Goat; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS422636
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422636

MBS422636 is an antibody targeting CACNB2. Also known as Goat anti-CACNB2 (aa565-579) Antibody. Reactive in Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CACNB2, Polyclonal Antibody

Full Product Name

Goat anti-CACNB2 (aa565-579) Antibody

Product Gene Name

anti-CACNB2 antibody

Product Synonym Names

CACNB2; calcium channel, voltage-dependent, beta 2 subunit; CACNLB2; CAVB2; FLJ23743; MYSB; CAB2; calcium channel voltage-dependent subunit beta 2; lambert-Eaton myasthenic syndrome antigen B; myasthenic (Lambert-Eaton) syndrome antigen B; voltage-depende; CAB2 antibody; CACNLB2 antibody; calcium channel voltage-dependent subunit beta 2 antibody; calcium channel; voltage-dependent; beta 2 subunit antibody; CAVB2 antibody; FLJ23743 antibody; lambert-Eaton myasthenic syndrome antigen B antibody; myasthenic (Lambert-Eaton) syndrome antigen B antibody; MYSB antibody; voltage-dependent L-type calcium channel subunit beta-2 antibody; CACNB2 antibody; CACNB2 (aa565-579)

Immunogen Sequence

ECNKQRSRHK SKDRY

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

CACNB2 peptide (MBS427647) is used for blocking the activity of CACNB2 antibody (MBS422636)

Molecular Weight

65,658 Da

OMIM

600003

Immunogen

Peptide with sequence ECNKQRSRHKSKDRY, from the C Terminus of the protein sequence according to NP_000715.2; NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1.

Epitope

C Terminus

Note

This antibody is expected to recognize all reported isoforms (NP_000715.2; NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1).

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CACNB2 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-CACNB2 antibody

Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 65kDa band observed in lysates of cell lines NIH3T3 and Jurkat (calculated MW of 68.1kDa according to NP_000715.2). Recommended concentration: 1-3ug/ml.

Other Notes

Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNB2. It may not necessarily be applicable to this product.

NCBI GI #

148232726

NCBI GeneID

783

NCBI Accession #

NP_000715.2

NCBI Related Accession #

NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1

UniProt Secondary Accession #

O00304; Q5QJ99; Q5QJA0; Q5VVG9; Q5VVH0; Q5VWV6; Q6TME1; Q6TME2; A6PVM5; A6PVM7; A6PVM8

UniProt Related Accession #

Q08289; AAB27916

GenBank Nucleotide #

NM_000724.3

NCBI Official Full Name

voltage-dependent L-type calcium channel subunit beta-2 isoform 1

NCBI Official Synonym Full Names

calcium voltage-gated channel auxiliary subunit beta 2

NCBI Official Symbol

CACNB2

NCBI Official Synonym Symbols

MYSB; CAVB2; CACNLB2

UniProt Protein Name

Voltage-dependent L-type calcium channel subunit beta-2

UniProt Synonym Protein Names

Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB

Protein Family

Voltage-dependent L-type calcium channel

UniProt Gene Name

CACNB2

UniProt Synonym Gene Names

CACNLB2; MYSB; CAB2; MYSB

UniProt Entry Name

CACB2_HUMAN

NCBI Protein Information

voltage-dependent L-type calcium channel subunit beta-2

NCBI Summary for CACNB2

This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]

UniProt Comments for CACNB2

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated calcium channel complex

Molecular Function: actin filament binding; calcium channel activity; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: neuromuscular junction development; positive regulation of calcium ion transport; synaptic transmission; visual perception

Disease: Brugada Syndrome 4

Research Articles on CACNB2

1. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNB2 antibody

Reference Product	PubMed Publications
CACNA1C antibody	>32 publications with CACNB2 and CACNA1C
CACNA2D1 antibody	>7 publications with CACNB2 and CACNA2D1
CACNA1D antibody	>4 publications with CACNB2 and CACNA1D
CACNB3 antibody	>3 publications with CACNB2 and CACNB3
CACNA1I antibody	>2 publications with CACNB2 and CACNA1I
CACNA1G antibody	>2 publications with CACNB2 and CACNA1G
CACNA1S antibody	>1 publications with CACNB2 and CACNA1S

Pathways associated with anti-CACNB2 antibody

Products by Pathway	Pathway Diagram
Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies	Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cardiac Conduction Pathway antibodies	Cardiac Conduction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram

Diseases associated with anti-CACNB2 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>29 publications with CACNB2 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>11 publications with CACNB2 and Nervous System Diseases
Brugada Syndrome 4 Antibodies	>5 publications with CACNB2 and Brugada Syndrome 4
Immune System Diseases Antibodies	>3 publications with CACNB2 and Immune System Diseases
Hypertrophy Antibodies	>2 publications with CACNB2 and Hypertrophy
Inflammation Antibodies	>2 publications with CACNB2 and Inflammation
Lung Neoplasms Antibodies	>1 publications with CACNB2 and Lung Neoplasms
Cell Transformation, Neoplastic Antibodies	>1 publications with CACNB2 and Cell Transformation, Neoplastic
Atrophy Antibodies	>1 publications with CACNB2 and Atrophy
Weight Loss Antibodies	>1 publications with CACNB2 and Weight Loss

Organs/Tissues associated with anti-CACNB2 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>30 publications with CACNB2 and Heart
Brain Antibodies	>17 publications with CACNB2 and Brain
Lung Antibodies	>6 publications with CACNB2 and Lung
Kidney Antibodies	>3 publications with CACNB2 and Kidney
Vascular Antibodies	>3 publications with CACNB2 and Vascular
Prostate Antibodies	>2 publications with CACNB2 and Prostate
Embryonic Tissue Antibodies	>2 publications with CACNB2 and Embryonic Tissue
Eye Antibodies	>1 publications with CACNB2 and Eye
Adrenal Gland Antibodies	>1 publications with CACNB2 and Adrenal Gland
Pancreas Antibodies	>1 publications with CACNB2 and Pancreas