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UGT8 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422644

MBS422644 is an antibody targeting UGT8. Also known as Goat anti-UGT8 Antibody. Reactive in Expected from sequence similarity: Human, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UGT8, Polyclonal Antibody
Full Product Name
Goat anti-UGT8 Antibody
Product Gene Name
anti-UGT8 antibody
Product Synonym Names
UGT8; UDP glycosyltransferase 8; CGT; UGT4; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; ceramide UDP-galactosyltransferase; cerebroside synthase; uridin; UGT8 antibody; UDP glycosyltransferase 8 antibody; CGT antibody; UGT4 antibody; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase antibody; UDP-galactose ceramide galactosyltransferase antibody; UDP-galactose-ceramide galactosyltransferase antibody; ceramide UDP-galactosyltransferase antibody; cerebroside synthase antibody
Immunogen Sequence
NGKYKRNGHI K
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
UGT8 peptide (MBS427577) is used for blocking the activity of UGT8 antibody (MBS422644)
Molecular Weight
61,438 Da
OMIM
601291
Immunogen
Peptide with sequence C-NGKYKRNGHIK, from the internal region of the protein sequence according to NP_003351.2.
Epitope
Internal region
Note
Reported variants represent identical protein: NP_001121646.1, NP_003351.2.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-UGT8 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-UGT8 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.

Western Blot (WB) of anti-UGT8 antibody

MCF7 overexpressing Human UGT8 and probed with (mock transfection in first lane). Primary incubation (1ug/ml) was overnight at 4C. Data provided by Tomasz Owczarek, Wroclaw University, Poland. Detected by chemiluminescence.
Goat Anti-UGT8 Polyclonal Antibody – Cat# MBS422644

Other Notes

Small volumes of anti-UGT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UGT8. It may not necessarily be applicable to this product.

NCBI GI #
40254471
NCBI GeneID
7368
NCBI Accession #
NP_003351.2
UniProt Secondary Accession #
O00196; B3KXU7
UniProt Related Accession #
Q16880
GenBank Nucleotide #
NM_003360.4
NCBI Official Full Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
NCBI Official Synonym Full Names
UDP glycosyltransferase 8
NCBI Official Symbol
UGT8
NCBI Official Synonym Symbols
CGT; UGT4
UniProt Protein Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Synonym Protein Names
Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase
Protein Family
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
UniProt Gene Name
UGT8
UniProt Synonym Gene Names
CGT; UGT4
UniProt Entry Name
CGT_HUMAN
NCBI Protein Information
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

NCBI Summary for UGT8

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
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UniProt Comments for UGT8

UGT8: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Belongs to the UDP-glycosyltransferase family.

Protein type: EC 2.4.1.45; Membrane protein, integral; Transferase; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: integral to membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity; glucuronosyltransferase activity; N-acylsphingosine galactosyltransferase activity; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

Biological Process: central nervous system development; cytoskeleton organization and biogenesis; flavonoid biosynthetic process; galactosylceramide biosynthetic process; glycosphingolipid metabolic process; neurite morphogenesis; paranodal junction assembly; peripheral nervous system development
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Research Articles on UGT8

1. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-UGT8 antibody

 Products by Pathway  Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sulfoglycolipids Biosynthesis, Ceramide/1-alkyl-2-acylglycerol => Sulfatide/seminolipid Pathway antibodies  Sulfoglycolipids Biosynthesis, Ceramide/1-alkyl-2-acylglycerol => Sulfatide/seminolipid Pathway Diagram

Diseases associated with anti-UGT8 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with UGT8 and Breast Neoplasms
 Lung Neoplasms Antibodies  >3 publications with UGT8 and Lung Neoplasms
 Brain Diseases Antibodies  >3 publications with UGT8 and Brain Diseases
 Lung Diseases Antibodies  >3 publications with UGT8 and Lung Diseases
 Abnormalities, Multiple Antibodies  >2 publications with UGT8 and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >2 publications with UGT8 and Congenital Abnormalities
 Kidney Diseases Antibodies  >2 publications with UGT8 and Kidney Diseases
 Adenocarcinoma Antibodies  >2 publications with UGT8 and Adenocarcinoma
 Acute Kidney Injury Antibodies  >1 publications with UGT8 and Acute Kidney Injury
 Weight Loss Antibodies  >1 publications with UGT8 and Weight Loss

Organs/Tissues associated with anti-UGT8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with UGT8 and Brain
 Kidney Antibodies  >4 publications with UGT8 and Kidney
 Lung Antibodies  >3 publications with UGT8 and Lung
 Liver Antibodies  >2 publications with UGT8 and Liver
 Intestine Antibodies  >1 publications with UGT8 and Intestine
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