PTGDS Antibody – Goat Polyclonal

PTGDS: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Isomerase; Secreted; EC 5.3.99.2; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Secreted, signal peptide

Cellular Component: cytoplasm; endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus; membrane; nucleus; rough endoplasmic reticulum

Molecular Function: fatty acid binding; isomerase activity; prostaglandin-D synthase activity; retinoid binding; transporter activity

Biological Process: fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of circadian sleep/wake cycle, sleep; transport