MTHFD1L Antibody – Goat Polyclonal

The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

MTHFD1L: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.4.3; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Ligase

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytosol; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; protein homodimerization activity

Biological Process: embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; folic acid and derivative biosynthetic process; folic acid and derivative metabolic process; folic acid metabolic process; formate metabolic process; neural tube closure; one-carbon compound metabolic process; tetrahydrofolate metabolic process